Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody

Este producto es parte de NOS1AP - Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein 
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025659
tested applications
ELISA, WB, FCM

Description

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Product specifications

Category
Primary Antibodies
Immunogen Target
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB, FCM
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O75052
Alias
NOS1AP,CAPON, nitric oxide synthase 1 adaptor protein, NPHS22
Background
Antibody anti-NOS1AP
Status
RUO

Descripción

NOS1AP, also known as CAPON, is an adaptor protein that binds to neuronal nitric oxide synthase (nNOS) via its PDZ-binding motif, regulating nNOS activity and nitric oxide (NO) production in neurons. It plays a critical role in neuronal development, synaptic signaling, and apoptosis by modulating NO signaling pathways. NOS1AP is highly expressed in the brain, particularly in regions responsible for cognition and memory, and it mediates downstream signaling of nNOS by interacting with proteins like Dexras1 and other cytoplasmic effectors. Dysregulation of NOS1AP is associated with neurological and psychiatric disorders such as schizophrenia, autism spectrum disorder, and ischemic brain injury due to abnormal NO signaling, which impacts neurotoxicity and synaptic plasticity. It also participates in cardiac function by influencing QT interval length and has been linked to arrhythmias and sudden cardiac death. Knockout and overexpression studies highlight its role in neuronal apoptosis, synaptic transmission, and cardiovascular regulation, making it a key regulator of NO-dependent signaling.

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