Human Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit
715€ (96 tests)
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name
Human Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx555974
tested applications
ELISA
Description
Human Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 1-3 weeks. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O75052 |
| Alias | NOS1AP,CAPON, nitric oxide synthase 1 adaptor protein, NPHS22 |
| Background | Elisa kits for NOS1AP |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
NOS1AP, also known as CAPON, is an adaptor protein that binds to neuronal nitric oxide synthase (nNOS) via its PDZ-binding motif, regulating nNOS activity and nitric oxide (NO) production in neurons. It plays a critical role in neuronal development, synaptic signaling, and apoptosis by modulating NO signaling pathways. NOS1AP is highly expressed in the brain, particularly in regions responsible for cognition and memory, and it mediates downstream signaling of nNOS by interacting with proteins like Dexras1 and other cytoplasmic effectors. Dysregulation of NOS1AP is associated with neurological and psychiatric disorders such as schizophrenia, autism spectrum disorder, and ischemic brain injury due to abnormal NO signaling, which impacts neurotoxicity and synaptic plasticity. It also participates in cardiac function by influencing QT interval length and has been linked to arrhythmias and sudden cardiac death. Knockout and overexpression studies highlight its role in neuronal apoptosis, synaptic transmission, and cardiovascular regulation, making it a key regulator of NO-dependent signaling.
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