Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody

Product specifications

Primary Antibodies

Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP)

Rabbit

Human

ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by antigen affinity column chromatography.

100 µg

1 mg

Lyophilized

ELISA, WB

Prior to lyophilization: 1% BSA and 0.02% NaN3.

Shipped within 7-15 working days.

Store at -20 °C. Avoid repeated freeze/thaw cycles.

No

BC112295

NOS1AP,CAPON, nitric oxide synthase 1 adaptor protein, NPHS22

Antibody anti-NOS1AP

RUO

Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. - 

Descripción

NOS1AP, also known as CAPON, is an adaptor protein that binds to neuronal nitric oxide synthase (nNOS) via its PDZ-binding motif, regulating nNOS activity and nitric oxide (NO) production in neurons. It plays a critical role in neuronal development, synaptic signaling, and apoptosis by modulating NO signaling pathways. NOS1AP is highly expressed in the brain, particularly in regions responsible for cognition and memory, and it mediates downstream signaling of nNOS by interacting with proteins like Dexras1 and other cytoplasmic effectors. Dysregulation of NOS1AP is associated with neurological and psychiatric disorders such as schizophrenia, autism spectrum disorder, and ischemic brain injury due to abnormal NO signaling, which impacts neurotoxicity and synaptic plasticity. It also participates in cardiac function by influencing QT interval length and has been linked to arrhythmias and sudden cardiac death. Knockout and overexpression studies highlight its role in neuronal apoptosis, synaptic transmission, and cardiovascular regulation, making it a key regulator of NO-dependent signaling.

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