Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody
357.5€ (100 µg)
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Name
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx122667
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the NOS1AP protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Immunogen: Recombinant fragment corresponding to 285-506 AA of human NOS1AP. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 55 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC112295 |
| Alias | NOS1AP,CAPON, nitric oxide synthase 1 adaptor protein, NPHS22 |
| Background | Antibody anti-NOS1AP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
NOS1AP, also known as CAPON, is an adaptor protein that binds to neuronal nitric oxide synthase (nNOS) via its PDZ-binding motif, regulating nNOS activity and nitric oxide (NO) production in neurons. It plays a critical role in neuronal development, synaptic signaling, and apoptosis by modulating NO signaling pathways. NOS1AP is highly expressed in the brain, particularly in regions responsible for cognition and memory, and it mediates downstream signaling of nNOS by interacting with proteins like Dexras1 and other cytoplasmic effectors. Dysregulation of NOS1AP is associated with neurological and psychiatric disorders such as schizophrenia, autism spectrum disorder, and ischemic brain injury due to abnormal NO signaling, which impacts neurotoxicity and synaptic plasticity. It also participates in cardiac function by influencing QT interval length and has been linked to arrhythmias and sudden cardiac death. Knockout and overexpression studies highlight its role in neuronal apoptosis, synaptic transmission, and cardiovascular regulation, making it a key regulator of NO-dependent signaling.
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