Mouse Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for NOS1AP
proveedor
Abbexareference
abx556154Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein concentrations in serum, plasma and other biological fluids.
Background
NOS1AP, also known as CAPON, is an adaptor protein that binds to neuronal nitric oxide synthase (nNOS) via its PDZ-binding motif, regulating nNOS activity and nitric oxide (NO) production in neurons. It plays a critical role in neuronal development, synaptic signaling, and apoptosis by modulating NO signaling pathways. NOS1AP is highly expressed in the brain, particularly in regions responsible for cognition and memory, and it mediates downstream signaling of nNOS by interacting with proteins like Dexras1 and other cytoplasmic effectors. Dysregulation of NOS1AP is associated with neurological and psychiatric disorders such as schizophrenia, autism spectrum disorder, and ischemic brain injury due to abnormal NO signaling, which impacts neurotoxicity and synaptic plasticity. It also participates in cardiac function by influencing QT interval length and has been linked to arrhythmias and sudden cardiac death. Knockout and overexpression studies highlight its role in neuronal apoptosis, synaptic transmission, and cardiovascular regulation, making it a key regulator of NO-dependent signaling.
Características del producto
category
ELISA Kits
immunogen target
Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma and other biological fluids.
size 1
96 tests
alias
NOS1AP,CAPON, nitric oxide synthase 1 adaptor protein, NPHS22
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
NOS1AP
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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