Family main features
ATP-binding cassette transporters form a superfamily of transport systems, representing one of the largest and potentially oldest gene families, spanning from prokaryotes to humans. ABC transporters typically comprise multiple subunits, with one or two acting as transmembrane proteins and one or two as membrane-associated ATPases. The ATPase subunits utilize energy derived from adenosine triphosphate (ATP) hydrolysis to facilitate the transport of various substrates across membranes. These transported substances include ions, amino acids, peptides, sugars, and predominantly hydrophilic molecules. Exporters function as pumps, expelling toxins and drugs from the cell. In gram-negative bacteria, exporters play a crucial role in transporting lipids and specific polysaccharides across membranes. Eukaryotes lack importers, and exporters are found in both prokaryotes and eukaryotes. The versatility of ABC transporters underscores their essential role in cellular transport processes across diverse organisms.The ABCA subfamily, consisting of 12 members to date, exhibits a high degree of sequence conservation and is primarily associated with lipid trafficking in various body locations. Mutations in some of these genes have been linked to severe hereditary diseases related to lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. Additionally, many ABCA subfamily members are hypothesized to participate in the subcellular sequestration of drugs, contributing to the resistance of several carcinoma cell lines against drug treatment.
ABCA Transporters share common structural features typical of ABC transporters:
The primary ligands and substrates for ABCA transporters include:
ABCA transporters are involved in several critical physiological functions:
Dysfunction or mutations in ABCA transporters can lead to a variety of diseases:
ATP Binding Cassette Transporter A2(ABCA2)
MRX,MXR,ABCP,BCRP,BMDP,MXR1,ABC15,BCRP1,CD338
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con ABCA2 - ATP Binding Cassette Transporter A2
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Esta página contiene 16 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | ABCA2 | abx385538 | Human ATP Binding Cassette Transporter A2 (ABCA2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.19 ng/ml | 687.5 | 96 tests | Q9BZC7 | RUO |
Abbexa | ABCA2 | abx500404 | Mouse ATP-binding cassette sub-family A member 2 (ABCA2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P41234 | RUO | ||
Abbexa | ABCA2 | abx500405 | Rat ATP Binding Cassette Transporter A2 (ABCA2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9ESR9 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | ABCA2 | FNab00027 | anti- ABCA2 antibody | human | polyclonal | Rabbit | ATP-binding cassette, sub-family A(ABC1), member 2 | IgG | Unconjugated | ELISA, WB, IF | 100µg | Q9BZC7 | RUO | |
Abbexa | ABCA2 | abx431059 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody | Human | Polyclonal | Goat | ATP Binding Cassette Transporter A2 (ABCA2) | Unconjugated | P-ELISA, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | ABCA2 | abx316615 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody (HRP) | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | HRP | ELISA | 162.5 | 20 µg | Q9BZC7 | RUO | |
Abbexa | ABCA2 | abx316616 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody (FITC) | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | FITC | 162.5 | 20 µg | Q9BZC7 | RUO | ||
Abbexa | ABCA2 | abx130548 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | ABCA2 | abx316617 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody (Biotin) | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | Biotin | ELISA | 162.5 | 20 µg | Q9BZC7 | RUO | |
Abbexa | ABCA2 | abx301860 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q9BZC7 | RUO | |
Abbexa | ABCA2 | abx230027 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | Unconjugated | ELISA, WB, IF/ICC | 350 | 100 µg | Q9BZC7 | RUO | |
Abbexa | ABCA2 | abx111159 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9BZC7 | RUO | |
Abbexa | ABCA2 | abx241340 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody | Human | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9BZC7 | RUO | |
Abbexa | ABCA2 | abx130547 | ATP Binding Cassette Transporter A2 (ABCA2) Antibody | Mouse | Polyclonal | Rabbit | ATP Binding Cassette Transporter A2 (ABCA2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ABCA2 | abx650371 | Human ATP Binding Cassette Transporter A2 (ABCA2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | Q9BZC7 | RUO |
Abbexa | ABCA2 | abx650372 | Mouse ATP Binding Cassette Transporter A2 (ABCA2) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P41234 | RUO |
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