Human ATP Binding Cassette Transporter A2 (ABCA2) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein ABCA2
proveedor
Abbexareference
abx650371Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ABCA2 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ABCA2 is a member of the ATP-binding cassette (ABC) transporter family, involved in lipid metabolism and intracellular cholesterol transport. It is primarily expressed in the brain, liver, and macrophages, where it plays a role in maintaining cellular lipid homeostasis and the transport of sterols and sphingolipids. Structurally, ABCA2 contains two transmembrane domains and two nucleotide-binding domains, which use ATP hydrolysis to drive lipid translocation across intracellular membranes. ABCA2 is implicated in myelin formation and neuronal function, highlighting its importance in the central nervous system. Dysregulation of ABCA2 expression has been associated with neurodegenerative diseases, such as Alzheimer’s disease, and certain cancers, where it may contribute to drug resistance by altering cellular lipid composition.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
ATP Binding Cassette Transporter A2 (ABCA2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu2201-Cys2436 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCA2
dry ice
No
availability
Shipped within 5-7 working days.
alias
MRX,MXR,ABCP,BCRP,BMDP,MXR1,ABC15,BCRP1,CD338
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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proveedor
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