Mouse ATP Binding Cassette Transporter A2 (ABCA2) Protein

Este producto es parte de ABCA2 - ATP Binding Cassette Transporter A2
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221€ (10 µg)

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935106861
info@markelab.com
name
Mouse ATP Binding Cassette Transporter A2 (ABCA2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650372
tested applications
WB, SDS-PAGE

Description

Mouse ABCA2 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
ATP Binding Cassette Transporter A2 (ABCA2)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 30.2 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Leu2201-Cys2434
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P41234
Alias
MRX,MXR,ABCP,BCRP,BMDP,MXR1,ABC15,BCRP1,CD338
Background
Protein ABCA2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ABCA2 is a member of the ATP-binding cassette (ABC) transporter family, involved in lipid metabolism and intracellular cholesterol transport. It is primarily expressed in the brain, liver, and macrophages, where it plays a role in maintaining cellular lipid homeostasis and the transport of sterols and sphingolipids. Structurally, ABCA2 contains two transmembrane domains and two nucleotide-binding domains, which use ATP hydrolysis to drive lipid translocation across intracellular membranes. ABCA2 is implicated in myelin formation and neuronal function, highlighting its importance in the central nervous system. Dysregulation of ABCA2 expression has been associated with neurodegenerative diseases, such as Alzheimer’s disease, and certain cancers, where it may contribute to drug resistance by altering cellular lipid composition.

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