Family main features
Agrin (AGRN) is a large proteoglycan protein primarily known for its crucial role in the formation and maintenance of neuromuscular junctions (NMJs), where nerve cells communicate with muscle cells. It is secreted by motor neurons and accumulates at the postsynaptic membrane of the NMJ, where it interacts with receptors on the muscle cell surface to orchestrate synapse formation and stability. Agrin's role in NMJ development is essential for proper muscle function and movement. Beyond the neuromuscular system, agrin is also implicated in various other biological processes, including synaptic plasticity, neuronal migration, and kidney development. Dysregulation of agrin expression or signaling has been linked to neuromuscular disorders, such as myasthenia gravis, and neurodevelopmental conditions, including autism spectrum disorders. Understanding the molecular mechanisms underlying agrin's functions offers insights into synaptic physiology and pathology, providing potential targets for therapeutic intervention in neuromuscular and neurological disorders. Ongoing research continues to unravel the multifaceted roles of agrin in cellular and synaptic biology.
Agrin is a complex protein with multiple functional domains:
Agrin is classified within the heparan sulfate proteoglycan family. There are several isoforms of agrin produced through alternative splicing, which differ in their ability to induce AChR clustering and their specific interactions with other proteins at the NMJ.
Function and Biological Significance:
Agrin is vital for several physiological processes:
Agrin interacts with numerous proteins and cellular components:
Mutations or dysfunction in agrin can lead to various clinical conditions:
Agrin (AGRN) is a crucial proteoglycan involved in the development and maintenance of the neuromuscular junction, primarily by inducing the clustering of acetylcholine receptors through interactions with LRP4 and MuSK. Its multifaceted structure includes domains essential for binding to ECM components and synaptic receptors. Agrin’s role extends beyond the NMJ to include broader interactions in the CNS and various tissues. Mutations or dysfunctions in agrin are associated with several neuromuscular disorders and other clinical conditions. Understanding agrin’s function and interactions provides critical insights into synaptic biology and potential therapeutic targets for related diseases.
Agrin (AGRN)
CMS8,AGRIN,CMSPPD
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con AGRN - Agrin
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 27 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGRN | abx354740 | Chicken Agrin (AGRN) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 662.5 | 96 tests | RUO | |
FineTest | AGRN | EH1477 | Human AGRN(Agrin) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O00468 | RUO | ||
Abbexa | AGRN | abx492615 | Human Agrin (AGRN) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 13.1 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | AGRN | abx150590 | Human Agrin (AGRN) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 13.1 pg/ml | 662.5 | 96 tests | RUO | |
Abbexa | AGRN | abx250758 | Human Agrin (AGRN) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 525 | 96 tests | O00468 | RUO |
Abbexa | AGRN | abx575437 | Human Agrin (AGRN) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 525 | 96 tests | RUO | |
Abbexa | AGRN | abx195070 | Human Agrin (AGRN) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | AGRN | abx353314 | Mouse Agrin (AGRN) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 587.5 | 96 tests | A2ASQ1 | RUO |
Abbexa | AGRN | abx355090 | Pig Agrin (AGRN) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | AGRN | abx256698 | Rat Agrin (AGRN) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 531.25 | 96 tests | P25304 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGRN | abx210621 | Agrin (AGRN) Antibody | Human | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | ELISA, IHC | 250 | 50 µl | O00468 | RUO | |
Abbexa | AGRN | abx211405 | Agrin (AGRN) Antibody | Human | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | ELISA, IHC | 250 | 50 µl | O00468 | RUO | |
Abbexa | AGRN | abx333691 | Agrin (AGRN) Antibody | Human | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | O00468 | RUO | |
Abbexa | AGRN | abx334622 | Agrin (AGRN) Antibody (Biotin) | Human | Polyclonal | Rabbit | Agrin (AGRN) | Biotin | ELISA | 162.5 | 20 µg | O00468 | RUO | |
Abbexa | AGRN | abx334620 | Agrin (AGRN) Antibody (HRP) | Human | Polyclonal | Rabbit | Agrin (AGRN) | HRP | ELISA | 162.5 | 20 µg | O00468 | RUO | |
Abbexa | AGRN | abx128778 | Agrin (AGRN) Antibody | Human | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O00468 | RUO | |
Abbexa | AGRN | abx171131 | Agrin (AGRN) Antibody | Human | Monoclonal | Mouse | Agrin (AGRN) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | AGRN | abx130616 | Agrin (AGRN) Antibody | Human | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O00468 | RUO | |
Abbexa | AGRN | abx334621 | Agrin (AGRN) Antibody (FITC) | Human | Polyclonal | Rabbit | Agrin (AGRN) | FITC | 162.5 | 20 µg | O00468 | RUO | ||
Abbexa | AGRN | abx037897 | Agrin (AGRN) Antibody | Human | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AGRN | abx129847 | Agrin (AGRN) Antibody | Mouse | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | A2ASQ1 | RUO | |
Abbexa | AGRN | abx130278 | Agrin (AGRN) Antibody | Rat | Polyclonal | Rabbit | Agrin (AGRN) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGRN | abx166410 | Human Agrin (AGRN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | RUO | |
Abbexa | AGRN | abx167580 | Rat Agrin (AGRN) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P25304 | RUO |
Abbexa | AGRN | abx168693 | Human Agrin (AGRN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | O00468 | RUO |
Abbexa | AGRN | abx167254 | Mouse Agrin (AGRN) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | A2ASQ1 | RUO |
Abbexa | AGRN | abx680142 | Rat Agrin (AGRN) Protein | Rat | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 5 µg | RUO |
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