Human AGRN (Agrin) ELISA Kit
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Name
Human AGRN (Agrin) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH1477
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O00468 |
| Alias | CMS8,AGRIN,CMSPPD |
| Background | Elisa kits for AGRN |
| Status | RUO |
Background
Agrin (AGRN) is a large proteoglycan protein primarily known for its crucial role in the formation and maintenance of neuromuscular junctions (NMJs), where nerve cells communicate with muscle cells. It is secreted by motor neurons and accumulates at the postsynaptic membrane of the NMJ, where it interacts with receptors on the muscle cell surface to orchestrate synapse formation and stability. Agrin's role in NMJ development is essential for proper muscle function and movement. Beyond the neuromuscular system, agrin is also implicated in various other biological processes, including synaptic plasticity, neuronal migration, and kidney development. Dysregulation of agrin expression or signaling has been linked to neuromuscular disorders, such as myasthenia gravis, and neurodevelopmental conditions, including autism spectrum disorders. Understanding the molecular mechanisms underlying agrin's functions offers insights into synaptic physiology and pathology, providing potential targets for therapeutic intervention in neuromuscular and neurological disorders. Ongoing research continues to unravel the multifaceted roles of agrin in cellular and synaptic biology.
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