Mouse Agrin (AGRN) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein AGRN
proveedor
Abbexareference
abx167254Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Agrin Protein is a recombinant Mouse protein expressed in E. coli.
Background
Agrin (AGRN) is a large proteoglycan protein primarily known for its crucial role in the formation and maintenance of neuromuscular junctions (NMJs), where nerve cells communicate with muscle cells. It is secreted by motor neurons and accumulates at the postsynaptic membrane of the NMJ, where it interacts with receptors on the muscle cell surface to orchestrate synapse formation and stability. Agrin's role in NMJ development is essential for proper muscle function and movement. Beyond the neuromuscular system, agrin is also implicated in various other biological processes, including synaptic plasticity, neuronal migration, and kidney development. Dysregulation of agrin expression or signaling has been linked to neuromuscular disorders, such as myasthenia gravis, and neurodevelopmental conditions, including autism spectrum disorders. Understanding the molecular mechanisms underlying agrin's functions offers insights into synaptic physiology and pathology, providing potential targets for therapeutic intervention in neuromuscular and neurological disorders. Ongoing research continues to unravel the multifaceted roles of agrin in cellular and synaptic biology.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Agrin (AGRN)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 32.7 kDa Observed MW (SDS-PAGE): 36 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 90 µg/ml Sequence Fragment: Arg1130-Cys1401 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AGRN
dry ice
No
availability
Shipped within 5-7 working days.
alias
CMS8,AGRIN,CMSPPD
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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