Rat Agrin (AGRN) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein AGRN
proveedor
Abbexareference
abx167580Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Agrin Protein is a recombinant Rat protein expressed in E. coli.
Background
Agrin (AGRN) is a large proteoglycan protein primarily known for its crucial role in the formation and maintenance of neuromuscular junctions (NMJs), where nerve cells communicate with muscle cells. It is secreted by motor neurons and accumulates at the postsynaptic membrane of the NMJ, where it interacts with receptors on the muscle cell surface to orchestrate synapse formation and stability. Agrin's role in NMJ development is essential for proper muscle function and movement. Beyond the neuromuscular system, agrin is also implicated in various other biological processes, including synaptic plasticity, neuronal migration, and kidney development. Dysregulation of agrin expression or signaling has been linked to neuromuscular disorders, such as myasthenia gravis, and neurodevelopmental conditions, including autism spectrum disorders. Understanding the molecular mechanisms underlying agrin's functions offers insights into synaptic physiology and pathology, providing potential targets for therapeutic intervention in neuromuscular and neurological disorders. Ongoing research continues to unravel the multifaceted roles of agrin in cellular and synaptic biology.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Agrin (AGRN)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 32.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala1206-Thr1475 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AGRN
dry ice
No
availability
Shipped within 5-7 working days.
alias
CMS8,AGRIN,CMSPPD
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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