Rat Agrin (AGRN) Protein
234€ (10 µg)
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name
Rat Agrin (AGRN) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167580
tested applications
WB, SDS-PAGE
Description
Rat Agrin Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Agrin (AGRN) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ala1206-Thr1475 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 32.4 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25304 |
| Alias | CMS8,AGRIN,CMSPPD |
| Background | Protein AGRN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Agrin (AGRN) is a large proteoglycan protein primarily known for its crucial role in the formation and maintenance of neuromuscular junctions (NMJs), where nerve cells communicate with muscle cells. It is secreted by motor neurons and accumulates at the postsynaptic membrane of the NMJ, where it interacts with receptors on the muscle cell surface to orchestrate synapse formation and stability. Agrin's role in NMJ development is essential for proper muscle function and movement. Beyond the neuromuscular system, agrin is also implicated in various other biological processes, including synaptic plasticity, neuronal migration, and kidney development. Dysregulation of agrin expression or signaling has been linked to neuromuscular disorders, such as myasthenia gravis, and neurodevelopmental conditions, including autism spectrum disorders. Understanding the molecular mechanisms underlying agrin's functions offers insights into synaptic physiology and pathology, providing potential targets for therapeutic intervention in neuromuscular and neurological disorders. Ongoing research continues to unravel the multifaceted roles of agrin in cellular and synaptic biology.
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