Family main features
AGMAT, also known as agmatinase, is an enzyme involved in the metabolism of the molecule agmatine. Agmatine is a naturally occurring compound derived from the amino acid arginine, and it plays various roles , including neurotransmission modulation, regulation of nitric oxide synthesis, and cellular signaling.AGMAT catalyzes the hydrolysis of agmatine into putrescine and urea. This reaction involves the cleavage of the guanidine group from agmatine, resulting in the formation of putrescine, a polyamine, and urea, a waste product of nitrogen metabolism. AGMAT plays a role in the regulation of agmatine levels within cells and tissues. By catalyzing the breakdown of agmatine, AGMAT contributes to the metabolic clearance of agmatine from the body. This process helps maintain appropriate levels of agmatine, which is important for its various physiological functions. AGMAT is predominantly found in the mitochondria, the energy-producing organelles of the cell. Its localization in the mitochondria suggests a role in cellular metabolism and energy production, as well as potential interactions with other mitochondrial enzymes and pathways. Agmatine itself has been implicated in numerous physiological processes, including neurotransmission modulation, neuroprotection, anti-inflammatory effects, and regulation of blood pressure. By regulating agmatine levels, AGMAT may indirectly influence these physiological processes. Dysregulation of agmatine metabolism has been associated with various diseases and conditions. For example, altered agmatine levels have been reported in neurological disorders such as depression, epilepsy, and Alzheimer's disease. Additionally, AGMAT gene polymorphisms have been linked to certain metabolic disorders and cardiovascular diseases.
AGMAT is characterized by specific structural domains that facilitate its enzymatic activity:
AGMAT belongs to the ureohydrolase family of enzymes, which also includes arginase and related enzymes involved in the hydrolysis of urea cycle intermediates. There are no distinct subtypes of AGMAT, but it is one of several enzymes involved in polyamine biosynthesis.
AGMAT has several important biological roles:
AGMAT interacts with various molecules and pathways within the cell:
Dysregulation or mutations in AGMAT can have significant clinical implications:
Agmatinase (AGMAT) is a mitochondrial enzyme crucial for polyamine biosynthesis, converting agmatine into putrescine and urea. This process is vital for cellular growth, proliferation, and differentiation. AGMAT plays a significant role in neurological function due to its influence on agmatine, a neurotransmitter, and in protecting cells from oxidative stress through polyamine production. Dysregulation of AGMAT is associated with neurological disorders, cancer, and metabolic imbalances, highlighting its importance in maintaining cellular and physiological health. Understanding AGMAT's structure, function, and clinical implications provides valuable insights into its role in health and disease.
Agmatinase Mitochondrial (AGMAT)
AGMAT
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con AGMAT - Agmatinase Mitochondrial l Elisa - Clia - Antibody - Protein
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Esta página contiene 12 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | AGMAT | abx516803 | Chicken Agmatinase, Mitochondrial (AGMAT) ELISA Kit | Chicken | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q90XD2 | RUO | ||
FineTest | AGMAT | EH1578 | Human AGMAT(Agmatinase, mitochondrial) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.781-50ng/ml | 96T | Q9BSE5 | RUO | ||
Abbexa | AGMAT | abx250868 | Human Agmatinase, Mitochondrial (AGMAT) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 687.5 | 96 tests | Q9BSE5 | RUO | |
Abbexa | AGMAT | abx516805 | Mouse Agmatinase, Mitochondrial (AGMAT) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.10 ng/ml | 687.5 | 96 tests | A2AS89 | RUO |
Abbexa | AGMAT | abx516806 | Rat Agmatinase, Mitochondrial (AGMAT) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q0D2L3 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGMAT | abx037569 | Agmatinase, Mitochondrial (AGMAT) Antibody | Human | Polyclonal | Rabbit | Agmatinase, Mitochondrial (AGMAT) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AGMAT | abx130690 | Agmatine Ureohydrolase (AGMAT) Antibody | Human | Polyclonal | Rabbit | Agmatine Ureohydrolase (AGMAT) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | AGMAT | abx037568 | Agmatinase, Mitochondrial (AGMAT) Antibody | Human | Polyclonal | Rabbit | Agmatinase, Mitochondrial (AGMAT) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AGMAT | abx102305 | Agmatine Ureohydrolase (AGMAT) Antibody | Human | Polyclonal | Rabbit | Agmatine Ureohydrolase (AGMAT) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | AGMAT | abx125499 | Agmatinase, Mitochondrial (AGMAT) Antibody | Human | Polyclonal | Rabbit | Agmatinase, Mitochondrial (AGMAT) | Unconjugated | WB, IF/ICC | 175 | 20 µl | Q9BSE5 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGMAT | abx167172 | Human Agmatine Ureohydrolase (AGMAT) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q9BSE5 | RUO |
Abbexa | AGMAT | abx065196 | Human Agmatine Ureohydrolase (AGMAT) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q9BSE5 | RUO |
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