Human Agmatine Ureohydrolase (AGMAT) Protein
247€ (10 µg)
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name
Human Agmatine Ureohydrolase (AGMAT) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065196
tested applications
WB, SDS-PAGE
Description
Human Agmatine Ureohydrolase (AGMAT) is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Agmatine Ureohydrolase (AGMAT) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Pro53-Ala151 Tag: N-terminal His tag and GST tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 42.3 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BSE5 |
| Alias | AGMAT |
| Background | Protein AGMAT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Agmatinase (AGMAT) is a mitochondrial enzyme involved in polyamine biosynthesis, catalyzing the conversion of agmatine into putrescine, a precursor for spermidine and spermine. These polyamines are crucial for cellular growth, DNA stabilization, protein translation, and stress adaptation. AGMAT is expressed in diverse tissues, including the brain, liver, and kidney, and it plays a central role in regulating neuronal health, liver detoxification, and cellular stress responses. Dysregulation of AGMAT affects polyamine homeostasis and has been linked to neurodegenerative disorders, including Alzheimer’s disease, due to its influence on oxidative stress and synaptic signaling. In cancer, AGMAT expression supports rapid cell division by enhancing polyamine levels, making it a potential biomarker and therapeutic target. Additionally, AGMAT’s role in modulating inflammatory pathways is being explored, as polyamines influence immune cell activity and cytokine production.
