Agmatinase, Mitochondrial (AGMAT) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
Agmatinase, Mitochondrial (AGMAT) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx125499
tested applications
ELISA, WB, IF/ICC
Description
AGMAT Antibody is a Rabbit Polyclonal against AGMAT.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Agmatinase, Mitochondrial (AGMAT) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BSE5 |
| Gene ID | 79814 |
| NCBI Accession | NP_079034.3 |
| Alias | AGMAT |
| Background | Antibody anti-AGMAT |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
Agmatinase (AGMAT) is a mitochondrial enzyme involved in polyamine biosynthesis, catalyzing the conversion of agmatine into putrescine, a precursor for spermidine and spermine. These polyamines are crucial for cellular growth, DNA stabilization, protein translation, and stress adaptation. AGMAT is expressed in diverse tissues, including the brain, liver, and kidney, and it plays a central role in regulating neuronal health, liver detoxification, and cellular stress responses. Dysregulation of AGMAT affects polyamine homeostasis and has been linked to neurodegenerative disorders, including Alzheimer’s disease, due to its influence on oxidative stress and synaptic signaling. In cancer, AGMAT expression supports rapid cell division by enhancing polyamine levels, making it a potential biomarker and therapeutic target. Additionally, AGMAT’s role in modulating inflammatory pathways is being explored, as polyamines influence immune cell activity and cytokine production.
