Family main features
The ACAN gene encodes the protein Aggrecan, also known as cartilage-specific proteoglycan core protein or chondroitin sulfate proteoglycan 1. As a member of the lectican family, Aggrecan is a crucial component of the extracellular matrix in cartilaginous tissue, providing resistance to compression. It is a proteoglycan modified with large carbohydrates, with the human form consisting of 2316 amino acids and exhibiting multiple isoforms due to alternative splicing. Aggrecan derives its name from its ability to form large aggregates in cartilage. Mutations in this gene may lead to skeletal dysplasia and spinal degeneration. Various transcript variants encoding different protein isoforms have been identified through alternative splicing.
Aggrecan has a complex structure composed of several key domains:
Aggrecan plays several critical roles in cartilage and other tissues:
Aggrecan interacts with various molecules and proteins in the extracellular matrix:
Mutations or alterations in aggrecan expression can lead to various health issues:
Aggrecan, encoded by the ACAN gene, is a vital component of cartilage that provides mechanical support, hydration, and structural integrity. Its interactions with hyaluronan, link protein, collagen, and other matrix components are crucial for maintaining healthy cartilage function. Mutations or degradation of aggrecan are linked to various skeletal disorders, including osteoarthritis, spondyloepiphyseal dysplasia, and intervertebral disc degeneration, underscoring its importance in joint health and disease.
Aggrecan Core Protein(ACAN)
AGC1,AGCAN,CSPG1,CSPGCP,MSK16,Cartilage-specific proteoglycan core protei,CSPC,Chondroitin sulfate proteoglycan core protein 1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con ACAN - Aggrecan Core Protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 47 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACAN | abx354642 | Chicken Aggrecan Core Protein (ACAN) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | ACAN | abx518787 | Cow Aggrecan Core Protein (ACAN) ELISA Kit | Cow | Serum,Plasma,Other biological fluids | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | P13608 | RUO | ||
Abbexa | ACAN | abx518789 | Dog Aggrecan Core Protein (ACAN) ELISA Kit | Dog | Serum,Plasma,Other biological fluids | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | Q28343 | RUO | ||
FineTest | ACAN | EH1995 | Human ACAN(Aggrecan core protein) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.781-50ng/ml | 96T | P16112 | RUO | ||
Abbexa | ACAN | abx190346 | Human Aggrecan Core Protein (ACAN) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 41.2 pg/ml - 30000 pg/ml | < 16.9 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | ACAN | abx195032 | Human Aggrecan Core Protein (ACAN) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | ACAN | abx251976 | Human Aggrecan Core Protein (ACAN) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 556.25 | 96 tests | P16112 | RUO |
Abbexa | ACAN | abx150588 | Human Aggrecan Core Protein (ACAN) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 662.5 | 96 tests | P16112 | RUO |
FineTest | ACAN | EM0695 | Mouse Acan(Aggrecan core protein) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q61282 | RUO | ||
Abbexa | ACAN | abx153609 | Mouse Aggrecan Core Protein (ACAN) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.37 ng/ml | 618.75 | 96 tests | Q61282 | RUO |
Abbexa | ACAN | abx493236 | Mouse Aggrecan Core Protein (ACAN) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 78.12 pg/ml - 5000 pg/ml | < 36 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | ACAN | abx355127 | Pig Aggrecan Core Protein (ACAN) ELISA Kit | Pig | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.38 ng/ml | 700 | 96 tests | RUO | |
Abbexa | ACAN | abx155030 | Rabbit Aggrecan Core Protein (ACAN) ELISA Kit | Rabbit | Serum,Plasma,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.23 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | ACAN | abx493238 | Rabbit Aggrecan Core Protein (ACAN) CLIA Kit | Rabbit | Serum, plasma and other biological fluids. | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.239 ng/ml | 812.5 | 96 tests | RUO | |
FineTest | ACAN | ER1573 | Rat Acan(Aggrecan core protein) ELISA Kit | rat | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | P07897 | RUO | ||
Abbexa | ACAN | abx493237 | Rat Aggrecan Core Protein (ACAN) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.137 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ACAN | abx155162 | Rat Aggrecan Core Protein (ACAN) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.14 ng/ml | 618.75 | 96 tests | P07897 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACAN | abx130592 | Aggrecan Core Protein (ACAN) Antibody | Cow | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | ACAN | abx413085 | Aggrecan Core Protein (ACAN) Antibody | Human | Monoclonal | Mouse | Aggrecan Core Protein (ACAN) | Unconjugated | ELISA, WB, IHC, IF/ICC, IP | 462.5 | 200 µg | P16112 | RUO | |
Abbexa | ACAN | abx273670 | Aggrecan Core Protein (ACAN) Antibody (FITC) | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | FITC | WB, IHC, IF/ICC | 412.5 | 200 µl | P16112 | RUO | |
Abbexa | ACAN | abx413086 | Aggrecan Core Protein (ACAN) Antibody | Human | Monoclonal | Mouse | Aggrecan Core Protein (ACAN) | Unconjugated | ELISA, WB, IHC, IP | 550 | 200 µg | P16112 | RUO | |
Abbexa | ACAN | abx272209 | Aggrecan Core Protein (ACAN) Antibody (Biotin) | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | P16112 | RUO | |
Abbexa | ACAN | abx100122 | Aggrecan Core Protein (ACAN) Antibody | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P16112 | RUO | |
Abbexa | ACAN | abx100121 | Aggrecan Core Protein (ACAN) Antibody | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P16112 | RUO | |
Abbexa | ACAN | abx171128 | Aggrecan Core Protein (ACAN) Antibody | Human | Monoclonal | Mouse | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P16112 | RUO | |
Abbexa | ACAN | abx100123 | Aggrecan Core Protein (ACAN) Antibody | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P16112 | RUO | |
Abbexa | ACAN | abx230213 | Aggrecan Core Protein (ACAN) Antibody | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P16112 | RUO | |
Abbexa | ACAN | abx147904 | Aggrecan Core Protein (ACAN) Antibody | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB | 300 | 50 µl | P16112 | RUO | |
Abbexa | ACAN | abx330183 | Aggrecan Core Protein Cleaved-Asp369 (ACAN Cleaved-D369) Antibody | Human | Polyclonal | Rabbit | Aggrecan Core Protein Cleaved-Asp369 (ACAN Cleaved-D369) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P16112 | RUO | |
Abbexa | ACAN | abx015530 | Aggrecan Core Protein (ACAN) Antibody | Human | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC | 43.75 | 10 µg | P16112 | RUO | |
Abbexa | ACAN | abx100124 | Aggrecan Core Protein (ACAN) Antibody | Mouse | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q61282 | RUO | |
Abbexa | ACAN | abx100125 | Aggrecan Core Protein (ACAN) Antibody | Mouse | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q61282 | RUO | |
Abbexa | ACAN | abx272806 | Aggrecan Core Protein (ACAN) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | Q61282 | RUO | |
Abbexa | ACAN | abx125483 | Aggrecan Core Protein (ACAN) Antibody | Mouse | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IF/ICC | 175 | 20 µl | P16112 | RUO | |
Abbexa | ACAN | abx100126 | Aggrecan Core Protein (ACAN) Antibody | Rat | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P07897 | RUO | |
Abbexa | ACAN | abx100127 | Aggrecan Core Protein (ACAN) Antibody | Rat | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P07897 | RUO | |
Abbexa | ACAN | abx124269 | Aggrecan Core Protein (ACAN) Antibody | Rat | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Unconjugated | IHC | 175 | 20 µl | P16112 | RUO | |
Abbexa | ACAN | abx273275 | Aggrecan Core Protein (ACAN) Antibody (Biotin) | Rat | Polyclonal | Rabbit | Aggrecan Core Protein (ACAN) | Biotin | WB, IHC, IF/ICC | 375 | 200 µl | P07897 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACAN | abx065190 | Mouse Aggrecan Core Protein (ACAN) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q61282 | RUO |
Abbexa | ACAN | abx065194 | Rat Aggrecan Core Protein (ACAN) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2275 | 1 mg | P07897 | RUO |
Abbexa | ACAN | abx065193 | Mouse Aggrecan Core Protein (ACAN) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2212.5 | 1 mg | Q61282 | RUO |
Abbexa | ACAN | abx065191 | Rat Aggrecan Core Protein (ACAN) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P07897 | RUO |
Abbexa | ACAN | abx652427 | Rabbit Aggrecan Core Protein (ACAN) Protein | Rabbit | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2112.5 | 1 mg | RUO | |
Abbexa | ACAN | abx065192 | Human Aggrecan Core Protein (ACAN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P16112 | RUO |
Abbexa | ACAN | abx166637 | Human Aggrecan Core Protein (ACAN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P16112 | RUO |
Abbexa | ACAN | abx065195 | Human Aggrecan Core Protein (ACAN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P16112 | RUO |
Abbexa | ACAN | abx166325 | Cow Aggrecan Core Protein (ACAN) Protein | Cow | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 437.5 | 50 µg | P13608 | RUO |
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