Rat Aggrecan Core Protein (ACAN) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Recombinant Aggrecan (AGC) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aggrecan Core Protein (ACAN) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 12.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu588-Arg684 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07897 |
| Alias | AGC1,AGCAN,CSPG1,CSPGCP,MSK16,Cartilage-specific proteoglycan core protei,CSPC,Chondroitin sulfate proteoglycan core protein 1 |
| Background | Protein ACAN |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The ACAN gene encodes the protein Aggrecan, also known as cartilage-specific proteoglycan core protein or chondroitin sulfate proteoglycan 1. As a member of the lectican family, Aggrecan is a crucial component of the extracellular matrix in cartilaginous tissue, providing resistance to compression. It is a proteoglycan modified with large carbohydrates, with the human form consisting of 2316 amino acids and exhibiting multiple isoforms due to alternative splicing. Aggrecan derives its name from its ability to form large aggregates in cartilage. Mutations in this gene may lead to skeletal dysplasia and spinal degeneration. Various transcript variants encoding different protein isoforms have been identified through alternative splicing.
Related Products
Human ACAN (Aggrecan core protein) ELISA Kit
Ver Producto
ACAN antibody
Aggrecan(ACAN), also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family(also including versican, brevican and neurocan). It is a major component of extracellular matrix of cartilagenous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site(PMID: 7852317; 9337874).
Ver Producto
Aggrecan Core Protein (ACAN) Antibody
Rabbit polyclonal antibody against Aggrecan protein. Immunogen region is N-terminal. Specificity is as follows for the reactive species: H:D369, R:D369.
Ver Producto