Aggrecan Core Protein (ACAN) Antibody
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Description
ACAN Antibody is a Rabbit Polyclonal Antibody against ACAN.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Aggrecan Core Protein (ACAN) Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 420-575 of human Aggrecan. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 261 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16112 |
| Gene ID | 176 |
| NCBI Accession | NP_037359.3 |
| Alias | AGC1,AGCAN,CSPG1,CSPGCP,MSK16,Cartilage-specific proteoglycan core protei,CSPC,Chondroitin sulfate proteoglycan core protein 1 |
| Background | Antibody anti-ACAN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The ACAN gene encodes the protein Aggrecan, also known as cartilage-specific proteoglycan core protein or chondroitin sulfate proteoglycan 1. As a member of the lectican family, Aggrecan is a crucial component of the extracellular matrix in cartilaginous tissue, providing resistance to compression. It is a proteoglycan modified with large carbohydrates, with the human form consisting of 2316 amino acids and exhibiting multiple isoforms due to alternative splicing. Aggrecan derives its name from its ability to form large aggregates in cartilage. Mutations in this gene may lead to skeletal dysplasia and spinal degeneration. Various transcript variants encoding different protein isoforms have been identified through alternative splicing.
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