Family main features
ADAMTS5, like other members of the ADAMTS family consists of multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. These motifs are involved in protein-protein interactions and may mediate interactions with other extracellular matrix components. ADAMTS5 is primarily known for its role in cartilage degradation, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. Like ADAMTS4, ADAMTS5 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix. It is implicated in the pathogenesis of osteoarthritis, where elevated levels of ADAMTS5 expression have been observed in osteoarthritic cartilage. ADAMTS5 has been extensively studied in the context of osteoarthritis. Inhibition of ADAMTS5 activity or expression has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation and disease progression.
ADAMTS5 has a complex multi-domain structure that is characteristic of the ADAMTS family:
ADAMTS5 belongs to the ADAMTS family, which includes enzymes characterized by their TSP1 motifs and metalloprotease domains. While ADAMTS5 does not have distinct subtypes, it shares functional and structural characteristics with other members of the ADAMTS family, particularly those involved in ECM degradation.
ADAMTS5 is involved in several key biological processes:
ADAMTS5 interacts with several proteins and cellular components:
ADAMTS5 has significant clinical implications, particularly in the context of joint health and inflammatory diseases:
ADAMTS5 is a crucial enzyme in the ADAMTS family, primarily involved in ECM remodeling and degradation, particularly in cartilage. Its multi-domain structure, including the metalloprotease and TSP1 domains, enables it to interact with various ECM components and cellular receptors. ADAMTS5 plays essential roles in maintaining joint health and is implicated in diseases such as osteoarthritis and rheumatoid arthritis. Understanding its structure, functions, interactions, and clinical implications provides valuable insights into its roles in various physiological and pathological processes.
ADAM metallopeptidase with thrombospondin type 1 motif 5(ADAMTS)
ADMP-2, Type 1 Motif 5,Aggrecanase-2,ADAMTS-5,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5,ADAM-TS5
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con ADAMTS5 - ADAM metallopeptidase with thrombospondin type 1 motif 5
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Esta página contiene 30 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | ADAMTS5 | abx519401 | Cow ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | Cow | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9TT92 | RUO | ||
FineTest | ADAMTS5 | EH2101 | Human ADAMTS5(A disintegrin and metalloproteinase with thrombospondin motifs 5) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9UNA0 | RUO | ||
Abbexa | ADAMTS5 | abx150554 | Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | ADAMTS5 | abx572602 | Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.16 ng/ml - 10 ng/ml | 0.09 ng/ml | 562.5 | 96 tests | RUO | |
Abbexa | ADAMTS5 | abx495836 | Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.112 ng/ml | 812.5 | 96 tests | RUO | |
FineTest | ADAMTS5 | EM1617 | Mouse ADAMTS5(A disintegrin and metalloproteinase with thrombospondin motifs 5) ELISA Kit | mouse | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9R001 | RUO | ||
Abbexa | ADAMTS5 | abx258026 | Mouse ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.1 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | ADAMTS5 | abx495837 | Mouse ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 7.0 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | ADAMTS5 | abx258641 | Rabbit ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | Rabbit | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | ADAMTS5 | abx495839 | Rabbit ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) CLIA Kit | Rabbit | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.059 ng/ml | 812.5 | 96 tests | RUO | |
FineTest | ADAMTS5 | ER1808 | Rat ADAMTS5(A Disintegrin And Metalloproteinase With Thrombospondin 5) ELISA Kit | rat | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | G3V673 | RUO | ||
Abbexa | ADAMTS5 | abx495838 | Rat ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) CLIA Kit | Rat | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.118 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ADAMTS5 | abx055161 | Rat ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 80 pg/ml - 4000 pg/ml | 687.5 | 96 tests | RUO | ||
Abbexa | ADAMTS5 | abx155146 | Rat ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAMTS5 | abx349569 | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) Antibody | Human | Polyclonal | Rabbit | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx128653 | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx027640 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx349572 | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) Antibody (Biotin) | Human | Polyclonal | Rabbit | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) | Biotin | ELISA | 162.5 | 20 µg | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx349570 | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) Antibody (HRP) | Human | Polyclonal | Rabbit | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) | HRP | ELISA | 162.5 | 20 µg | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx349571 | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) Antibody (FITC) | Human | Polyclonal | Rabbit | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) | FITC | 162.5 | 20 µg | Q9UNA0 | RUO | ||
Abbexa | ADAMTS5 | abx370578 | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody Pair | Human | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) | ELISA | 1462.5 | 5 × 96 tests | RUO | |||||
Abbexa | ADAMTS5 | abx171039 | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody | Human | Monoclonal | Mouse | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | ADAMTS5 | abx214797 | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx007374 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) | Unconjugated | WB | 175 | 20 µl | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx242427 | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx033401 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) Antibody | Mouse | Polyclonal | Rabbit | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9UNA0 | RUO | |
Abbexa | ADAMTS5 | abx130060 | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody | Rat | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q6TY19 | RUO | |
Abbexa | ADAMTS5 | abx171040 | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody | Rat | Monoclonal | Mouse | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) | Unconjugated | WB, IHC, IF/ICC | 850 | 1 ml | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAMTS5 | abx167701 | Rat A Disintegrin And Metalloproteinase With ThrombosPondin 5 (ADAMTS5) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | ADAMTS5 | abx168116 | Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9UNA0 | RUO |
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