A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody
819€ (1 ml)
819€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx171039
tested applications
WB, IHC, IF/ICC
Descripción del producto
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | ADMP-2, Type 1 Motif 5,Aggrecanase-2,ADAMTS-5,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5,ADAM-TS5 |
| Availability | Please enquire. |
| Background | Antibody anti-ADAMTS5 |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Category | Primary Antibodies |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Host | Mouse |
| Immunogen Target | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) |
| Name | A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Antibody |
| Price | 819 |
| Provider | Abbexa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx171039 |
| Size 1 | 1 ml |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | WB, IHC, IF/ICC |
Descripcion del producto en español
Background en español
ADAMTS5, like other members of the ADAMTS family consists of multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. These motifs are involved in protein-protein interactions and may mediate interactions with other extracellular matrix components. ADAMTS5 is primarily known for its role in cartilage degradation, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. Like ADAMTS4, ADAMTS5 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix. It is implicated in the pathogenesis of osteoarthritis, where elevated levels of ADAMTS5 expression have been observed in osteoarthritic cartilage. ADAMTS5 has been extensively studied in the context of osteoarthritis. Inhibition of ADAMTS5 activity or expression has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation and disease progression.
Related Products
Human ADAMTS5(A disintegrin and metalloproteinase with thrombospondin motifs 5) ELISA Kit
Ver Producto
Mouse ADAMTS5(A disintegrin and metalloproteinase with thrombospondin motifs 5) ELISA Kit
Ver Producto