Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Protein

Este producto es parte de ADAMTS5 - ADAM metallopeptidase with thrombospondin type 1 motif 5
Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Protein

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935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ADAMTS5

proveedor

Abbexa

reference

abx168116

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ADAMTS5 Protein is a recombinant Human protein expressed in E. coli.


Background

ADAMTS5, like other members of the ADAMTS family consists of multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. These motifs are involved in protein-protein interactions and may mediate interactions with other extracellular matrix components. ADAMTS5 is primarily known for its role in cartilage degradation, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. Like ADAMTS4, ADAMTS5 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix. It is implicated in the pathogenesis of osteoarthritis, where elevated levels of ADAMTS5 expression have been observed in osteoarthritic cartilage. ADAMTS5 has been extensively studied in the context of osteoarthritis. Inhibition of ADAMTS5 activity or expression has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation and disease progression.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 19.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu485-Pro622 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ADAMTS5


dry ice

No


availability

Shipped within 5-7 working days.


alias

ADMP-2, Type 1 Motif 5,Aggrecanase-2,ADAMTS-5,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5,ADAM-TS5


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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