Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ADAMTS5
proveedor
Abbexareference
abx168116Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ADAMTS5 Protein is a recombinant Human protein expressed in E. coli.
Background
ADAMTS5, like other members of the ADAMTS family consists of multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. These motifs are involved in protein-protein interactions and may mediate interactions with other extracellular matrix components. ADAMTS5 is primarily known for its role in cartilage degradation, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. Like ADAMTS4, ADAMTS5 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix. It is implicated in the pathogenesis of osteoarthritis, where elevated levels of ADAMTS5 expression have been observed in osteoarthritic cartilage. ADAMTS5 has been extensively studied in the context of osteoarthritis. Inhibition of ADAMTS5 activity or expression has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation and disease progression.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 19.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu485-Pro622 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ADAMTS5
dry ice
No
availability
Shipped within 5-7 working days.
alias
ADMP-2, Type 1 Motif 5,Aggrecanase-2,ADAMTS-5,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5,ADAM-TS5
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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