935106861
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Precio
687.5€ (96 tests)
Cow ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) concentrations in serum, plasma and other biological fluids.
ADAMTS5, like other members of the ADAMTS family consists of multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. These motifs are involved in protein-protein interactions and may mediate interactions with other extracellular matrix components. ADAMTS5 is primarily known for its role in cartilage degradation, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. Like ADAMTS4, ADAMTS5 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix. It is implicated in the pathogenesis of osteoarthritis, where elevated levels of ADAMTS5 expression have been observed in osteoarthritic cartilage. ADAMTS5 has been extensively studied in the context of osteoarthritis. Inhibition of ADAMTS5 activity or expression has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation and disease progression.
ELISA Kits
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5)
Cow
0.156 ng/ml - 10 ng/ml
Quantitative
Colorimetric
Serum,Plasma,Other biological fluids
96 tests
ADMP-2, Type 1 Motif 5,Aggrecanase-2,ADAMTS-5,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5,ADAM-TS5
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
ADAMTS5
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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