Human ADAMTS5(A disintegrin and metalloproteinase with thrombospondin motifs 5) ELISA Kit

Product specifications

ELISA Kits

human

Colorimetric

Quantitative

Sandwich ELISA, Double Antibody

0.156-10ng/ml

96T

Serum,Plasma,Tissue homogenates,Other biological fluids

Shipped within 10-14 working days.

2-8 °C for 6 months

Q9UNA0

ADMP-2, Type 1 Motif 5,Aggrecanase-2,ADAMTS-5,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5,ADAM-TS5

Elisa Kits ADAMTS5

RUO

ADAMTS5, like other members of the ADAMTS family consists of multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. These motifs are involved in protein-protein interactions and may mediate interactions with other extracellular matrix components. ADAMTS5 is primarily known for its role in cartilage degradation, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. Like ADAMTS4, ADAMTS5 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix. It is implicated in the pathogenesis of osteoarthritis, where elevated levels of ADAMTS5 expression have been observed in osteoarthritic cartilage. ADAMTS5 has been extensively studied in the context of osteoarthritis. Inhibition of ADAMTS5 activity or expression has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation and disease progression.

Related Products

Human ADAMTS5(A disintegrin and metalloproteinase with thrombospondin motifs 5) ELISA Kit

Ver Producto

Mouse ADAMTS5(A disintegrin and metalloproteinase with thrombospondin motifs 5) ELISA Kit

Ver Producto

Rat ADAMTS5(A Disintegrin And Metalloproteinase With Thrombospondin 5) ELISA Kit

Ver Producto