Family main features
The ABI (ABL Interactor) family of proteins is involved in cellular signaling pathways, particularly those regulated by the ABL tyrosine kinase. These proteins were initially identified as interacting partners of the ABL oncogene, a tyrosine kinase involved in various cellular processes, including cell growth, survival, and motility. The ABI family plays crucial roles in cytoskeletal dynamics, cell migration, and signal transduction.ABI1, also known as ABL Interactor 1 or Abelson interactor 1, plays a crucial role in cell signaling pathways, particularly in the regulation of actin dynamics and cytoskeletal rearrangements. ABI1 is involved in processes such as cell migration, adhesion, and proliferation.The ABI1 gene encodes a protein that functions as an adapter molecule, linking various signaling proteins together. It interacts with ABL (Abelson tyrosine kinase) , hence its name, to regulate actin polymerization and cytoskeletal organization.ABI1 is also implicated in cancer development and progression. It is often found to be dysregulated in various types of cancer, including breast cancer, prostate cancer, and leukemia. Dysregulation of ABI1 can lead to aberrant cell signaling, promoting tumor growth, invasion, and metastasis.Furthermore, ABI1 has been implicated in neurological disorders such as Alzheimer's disease, where it may contribute to synaptic dysfunction and neurodegeneration.ABL2 is a cytoplasmic tyrosine kinase closely associated with ABL1. These proteins share similarity in their tyrosine kinase domains, extending towards the amino-terminal to encompass the SH2 and SH3 domains. ABL2 is present in both normal and tumor cells, with elevated expression observed in KRAS mutant non-small cell lung cancer. The ABL2 gene produces two variants with distinct amino termini, each approximately 12-kb in length
The ABI family proteins have distinct structural features that enable their functions:
The ABI family includes several members, with the most well-characterized being:
The ABI family proteins are essential for various cellular functions:
ABI proteins interact with various partners to exert their functions:
Dysfunction or alterations in ABI proteins can contribute to several clinical conditions:
The ABI family of proteins plays crucial roles in regulating cytoskeletal dynamics, cell migration, and signal transduction through their interactions with ABL kinase and other actin-regulatory proteins. These functions are vital for processes such as cell movement, neuronal development, and immune responses. Dysregulation or mutations in ABI proteins can lead to significant clinical conditions, including cancer, neurological disorders, and immune diseases. The ABI family thus represents an important group of proteins in maintaining cellular structure and signaling integrity.
ABL Interactor 1 (ABI1)
ABI1, ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1,Abelson interactor 1
ABL Interactor 2 (ABI2)
AIP1,ABI-2,ABI2B,AIP-1, AblBP3,argBP1,SSH3BP2,argBPIA,argBPIB,Abelson interactor 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con ABI - ABL Interactor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 23 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ABI1 | abx150514 | Human ABL Interactor 1 (ABI1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | Q8IZP0 | RUO |
Abbexa | ABI1 | abx495765 | Human ABL Interactor 1 (ABI1) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.055 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ABI2 | abx385558 | Human Abl Interactor 2 (ABI2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.19 ng/ml | 687.5 | 96 tests | Q9NYB9 | RUO |
Abbexa | ABI1 | abx500541 | Mouse Abl interactor 1 (ABI1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8CBW3 | RUO | ||
Abbexa | ABI2 | abx500544 | Mouse Abl interactor 2 (ABI2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P62484 | RUO | ||
Abbexa | ABI1 | abx500542 | Rat ABL Interactor 1 (ABI1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9QZM5 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | ABI2 | FNab00052 | anti- ABI2 antibody | human | polyclonal | Rabbit | abl interactor 2 | IgG | Unconjugated | ELISA, WB, IF, IHC | 100µg | Q9NYB9 | RUO | |
Abbexa | ABI1 | abx128353 | ABL Interactor 1 (ABI1) Antibody | Human | Polyclonal | Rabbit | ABL Interactor 1 (ABI1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q8IZP0 | RUO | |
Abbexa | ABI1 | abx171044 | ABL Interactor 1 (ABI1) Antibody | Human | Monoclonal | Mouse | ABL Interactor 1 (ABI1) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | ABI1 | abx033986 | ABL Interactor 1 (ABI1) Antibody | Human | Polyclonal | Rabbit | ABL Interactor 1 (ABI1) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 250 | 80 µl | Q8IZP0 | RUO | |
Abbexa | ABI1 | abx242187 | ABL Interactor 1 (ABI1) Antibody | Human | Polyclonal | Rabbit | ABL Interactor 1 (ABI1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q8IZP0 | RUO | |
Abbexa | ABI1 | abx327807 | ABL Interactor 1 (ABI1) Antibody | Human | Polyclonal | Rabbit | ABL Interactor 1 (ABI1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q8IZP0 | RUO | |
Abbexa | ABI1 | abx110743 | ABL Interactor 1 (ABI1) Antibody | Human | Polyclonal | Rabbit | ABL Interactor 1 (ABI1) | Unconjugated | ELISA, IF/ICC | 612.5 | 100 µl | Q8IZP0 | RUO | |
Abbexa | ABI1 | abx241620 | ABL Interactor 1 (ABI1) Antibody | Human | Polyclonal | Rabbit | ABL Interactor 1 (ABI1) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8IZP0 | RUO | |
Abbexa | ABI2 | abx334533 | Abl Interactor 2 (ABI2) Antibody (HRP) | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | HRP | ELISA | 162.5 | 20 µg | Q9NYB9 | RUO | |
Abbexa | ABI2 | abx334535 | Abl Interactor 2 (ABI2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | Biotin | ELISA | 162.5 | 20 µg | Q9NYB9 | RUO | |
Abbexa | ABI2 | abx334534 | Abl Interactor 2 (ABI2) Antibody (FITC) | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | FITC | 162.5 | 20 µg | Q9NYB9 | RUO | ||
Abbexa | ABI2 | abx333822 | Abl Interactor 2 (ABI2) Antibody | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q9NYB9 | RUO | |
Abbexa | ABI2 | abx037957 | Abl Interactor 2 (ABI2) Antibody | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ABI2 | abx026891 | Abl Interactor 2 (ABI2) Antibody | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | Unconjugated | ELISA, WB, FCM | 250 | 80 µl | Q9NYB9 | RUO | |
Abbexa | ABI2 | abx230052 | Abl Interactor 2 (ABI2) Antibody | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | Q9NYB9 | RUO | |
Abbexa | ABI2 | abx110742 | Abl Interactor 2 (ABI2) Antibody | Human | Polyclonal | Rabbit | Abl Interactor 2 (ABI2) | Unconjugated | ELISA, WB, IF/ICC | 612.5 | 100 µl | Q9NYB9 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ABI1 | abx166774 | Human ABL Interactor 1 (ABI1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO |
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