Abl Interactor 2 (ABI2) Antibody

Background

ABI2, like ABI1, is a multifunctional adaptor protein involved in regulating actin dynamics, signal transduction, and various cellular functions. ABL Interactor 2, is a cytoplasmic protein that shares structural similarities with ABI1. It contains functional domains including a proline-rich region, a Src homology 3 (SH3) domain, a Src homology 2 (SH2) domain, and a C-terminal domain. These domains enable ABI2 to interact with various binding partners and participate in diverse cellular processes. Similar to ABI1, ABI2 is involved in the regulation of actin cytoskeleton dynamics. It interacts with actin-binding proteins and signaling molecules to modulate actin polymerization, cell migration, adhesion, and morphogenesis. ABI2 serves as an adaptor protein that links cell surface receptors to intracellular signaling pathways. Through its SH3 and SH2 domains, ABI2 interacts with proteins such as ABL kinases, mediating signaling cascades that regulate cell proliferation, survival, and differentiation.ABI2 participates in various cellular processes including cell adhesion, migration, invasion, and endocytosis. It plays a role in the regulation of cell growth, differentiation, and apoptosis. Dysregulation of ABI2 expression or function can impact these cellular functions and contribute to disease pathogenesis.Dysregulation of ABI2 has been implicated in cancer progression. ABI2 can function as a tumor suppressor or oncogene depending on the cellular context. Aberrant expression or activity of ABI2 may promote cancer cell proliferation, migration, invasion, and metastasis through its effects on actin dynamics and signaling pathways.Mutations in ABI2 have been associated with neurological disorders such as Alzheimer's disease and Parkinson's disease. Altered ABI2 function may disrupt neuronal processes, synaptic plasticity, and neuronal survival, contributing to the pathogenesis of these disorders.