Human ABL Interactor 1 (ABI1) Protein

Product specifications

Proteins and Peptides

ABL Interactor 1 (ABI1)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 24.3 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Pro182
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

ABI1, ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1,Abelson interactor 1

Protein ABI1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ABI1, also known as ABL Interactor 1, is a cytoplasmic protein that plays a role in regulating actin cytoskeleton dynamics and cell signaling pathways. It contains several functional domains, including a proline-rich region, a Src homology 3 (SH3) domain, a Src homology 2 (SH2) domain, and a C-terminal domain. These domains enable ABI1 to interact with various binding partners and participate in multiple cellular processes. ABI1 regulates actin cytoskeleton dynamics by interacting with actin-binding proteins and signaling molecules. It modulates actin polymerization and cytoskeletal rearrangements, which are essential for cell migration, adhesion, and morphogenesis.ABI1 acts as an adaptor protein that links cell surface receptors to intracellular signaling pathways. Through its SH3 and SH2 domains, ABI1 interacts with proteins such as ABL kinases, which regulate signaling cascades involved in cell proliferation, survival, and differentiation. Dysregulation of ABI1 expression or function has been associated with cancer progression. ABI1 can act as a tumor suppressor or oncogene depending on the context. Aberrant expression of ABI1 may promote cancer cell proliferation, migration, invasion, and metastasis through its effects on actin dynamics and signaling pathways. ABI1 mutations have also been linked to neurological disorders such as autism spectrum disorders and intellectual disabilities. Altered ABI1 function may disrupt neuronal development and synaptic plasticity, contributing to the pathogenesis of these conditions.

Related Products

ABL Interactor 1 (ABI1) Antibody

ABI1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, this protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling.

Ver Producto

ABL Interactor 1 (ABI1) Antibody

Abl-Interactor 1 Antibody is a Rabbit Polyclonal antibody against Abl-Interactor 1.

Ver Producto

ABL Interactor 1 (ABI1) Antibody

ABL Interactor 1 Antibody is a Rabbit Polyclonal against ABL Interactor 1.

Ver Producto