Human Abl Interactor 2 (ABI2) ELISA Kit
715€ (96 tests)
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name
Human Abl Interactor 2 (ABI2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385558
tested applications
ELISA
Description
Human Abl Interactor 2 (ABI2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Abl Interactor 2 (ABI2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Abl Interactor 2 (ABI2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NYB9 |
| Gene ID | 10152 |
| OMIM | 606442 |
| Alias | AIP1,ABI-2,ABI2B,AIP-1, AblBP3,argBP1,SSH3BP2,argBPIA,argBPIB,Abelson interactor 2 |
| Background | Elisa kits for ABI2 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ABI2, like ABI1, is a multifunctional adaptor protein involved in regulating actin dynamics, signal transduction, and various cellular functions. ABL Interactor 2, is a cytoplasmic protein that shares structural similarities with ABI1. It contains functional domains including a proline-rich region, a Src homology 3 (SH3) domain, a Src homology 2 (SH2) domain, and a C-terminal domain. These domains enable ABI2 to interact with various binding partners and participate in diverse cellular processes. Similar to ABI1, ABI2 is involved in the regulation of actin cytoskeleton dynamics. It interacts with actin-binding proteins and signaling molecules to modulate actin polymerization, cell migration, adhesion, and morphogenesis. ABI2 serves as an adaptor protein that links cell surface receptors to intracellular signaling pathways. Through its SH3 and SH2 domains, ABI2 interacts with proteins such as ABL kinases, mediating signaling cascades that regulate cell proliferation, survival, and differentiation.ABI2 participates in various cellular processes including cell adhesion, migration, invasion, and endocytosis. It plays a role in the regulation of cell growth, differentiation, and apoptosis. Dysregulation of ABI2 expression or function can impact these cellular functions and contribute to disease pathogenesis.Dysregulation of ABI2 has been implicated in cancer progression. ABI2 can function as a tumor suppressor or oncogene depending on the cellular context. Aberrant expression or activity of ABI2 may promote cancer cell proliferation, migration, invasion, and metastasis through its effects on actin dynamics and signaling pathways.Mutations in ABI2 have been associated with neurological disorders such as Alzheimer's disease and Parkinson's disease. Altered ABI2 function may disrupt neuronal processes, synaptic plasticity, and neuronal survival, contributing to the pathogenesis of these disorders.
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