Vasoactive intestinal polypeptide receptor 2 (VIPR2) Antibody
260€ (50 µl)
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Name
Vasoactive intestinal polypeptide receptor 2 (VIPR2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx241450
Tested Applications
ELISA, IHC
Description
VIPR2 Antibody is a Rabbit Polyclonal against VIPR2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Vasoactive intestinal polypeptide receptor 2 (VIPR2) Immunogen: Synthetic peptide of human VIPR2. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41587 |
| Gene ID | 7434 |
| Alias | VIPR2,VPAC,Helodermin-preferring VIP recepto,Pituitary adenylate cyclase-activating polypeptide type III recepto,PACAP type III recepto,PACAP-R-,PACAP-R,VIP2R |
| Background | Antibody anti-VIPR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
VIPR2 is a G protein-coupled receptor activated by vasoactive intestinal peptide (VIP), a neuropeptide that plays a central role in regulating smooth muscle relaxation, vasodilation, and neurotransmission. VIPR2 primarily couples to Gs proteins, activating adenylate cyclase, which increases intracellular cAMP levels and leads to the relaxation of smooth muscle cells and dilation of blood vessels. It is expressed in the smooth muscle of the gastrointestinal tract, heart, lungs, and brain. VIPR2 has significant roles in regulating gastrointestinal motility, vascular tone, and immune cell activity. Dysregulation of VIPR2 signaling is implicated in diseases such as asthma, irritable bowel syndrome (IBS), and inflammatory disorders. VIPR2 antagonists are being studied for their potential in treating these diseases, as they could help reduce excessive smooth muscle contraction and inflammation.
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