Vascular Endothelial Growth Factor D (FIGF) Antibody
312€ (60 µl)
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name
Vascular Endothelial Growth Factor D (FIGF) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001107
tested applications
WB
Description
FIGF Antibody is a Rabbit Polyclonal antibody against FIGF. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Vascular Endothelial Growth Factor D (FIGF) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43915 |
| Gene ID | 2277 |
| NCBI Accession | NP_004460.1 |
| Alias | FIGF,VEGF-D,c-Fos-induced growth factor |
| Background | Antibody anti-VEGFD |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
VEGFD is a member of the vascular endothelial growth factor family that primarily promotes lymphangiogenesis and angiogenesis by binding to VEGF receptors VEGFR-2 and VEGFR-3 on endothelial cells VEGFD plays a key role in the development of lymphatic vessels during embryogenesis and in tissue repair by stimulating endothelial cell proliferation and migration It is also involved in cancer progression where VEGFD expression enhances tumor angiogenesis, lymphatic metastasis, and the spread of cancer cells Elevated levels of VEGFD have been observed in cancers such as breast cancer, melanoma, and lung cancer where it promotes the formation of new lymphatic vessels for tumor dissemination Its role in vascular biology makes VEGFD a target for therapies designed to inhibit lymphangiogenesis and reduce tumor metastasis
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