Transmembrane Emp24 Domain-Containing Protein 5 (TMED5) Antibody

Este producto es parte de TMED - Transmembrane emp24 domain-containing
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Transmembrane Emp24 Domain-Containing Protein 5 (TMED5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145007
tested applications
ELISA, WB, IHC

Description

TMED5 Antibody is a Rabbit Polyclonal against TMED5.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Transmembrane Emp24 Domain-Containing Protein 5 (TMED5)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
BC016365
Alias
CGI-100, p24g2, p28,p24 family protein gamma-2 ,p24gamma2
Background
Antibody anti-TMED5
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

TMED5 is a member of the p24 trafficking protein family that regulates protein transport and sorting between the ER and the Golgi apparatus. It functions as a cargo receptor by recognizing and packaging proteins into COPII-coated vesicles for export from the ER, while facilitating vesicle retrieval back to the ER through interactions with COPI machinery. TMED5 maintains ER-Golgi communication and contributes to protein quality control, ensuring proper folding and maturation of secretory and membrane proteins. It is expressed in multiple tissues and is essential for cellular homeostasis, especially in rapidly growing or secretory cells. TMED5 also plays a role in regulating growth factor signaling pathways and maintaining Golgi structure. Dysregulation of TMED5 has been linked to developmental defects and cancers due to altered trafficking dynamics and impaired protein secretion. Knockdown studies demonstrate defective vesicle transport, Golgi fragmentation, and disrupted secretory pathway balance, emphasizing its role in protein trafficking, organelle integrity, and cellular signaling.
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