Transcription Factor AP-2 Gamma (TFAP2C) Antibody
273€ (100 µg)
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935106861
info@markelab.com
name
Transcription Factor AP-2 Gamma (TFAP2C) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx018183
tested applications
ELISA, WB
Description
AP2 gamma Antibody is a Mouse Monoclonal antibody against AP2-gamma.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transcription Factor AP-2 Gamma (TFAP2C) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from ascites by Protein A chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Citrate-Tris-HCl, pH 7.0, with 0.02% Proclin-300. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_003222.3 |
| Alias | AP2-GAMMA,ERF1,TFAP2G,hAP-2g,Activating enhancer-binding protein 2 gamma,Transcription factor ERF-1 |
| Background | Antibody anti-TFAP2C |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
TFAP2C, another member of the AP-2 family, regulates the transcription of genes involved in embryogenesis, cell proliferation, and epithelial cell differentiation. It is critical for early embryonic development, including trophoblast differentiation, placental development, and mammary gland morphogenesis. TFAP2C acts as a key regulator of estrogen receptor (ER)-mediated signaling in breast cancer, where it promotes tumor cell growth, survival, and metastasis. TFAP2C also regulates epithelial-mesenchymal transition (EMT), contributing to cancer progression and metastatic dissemination. Its expression is elevated in breast, ovarian, and prostate cancers, where it serves as both a prognostic marker and therapeutic target. Knockout studies reveal impaired placental development, defective cell differentiation, and embryonic lethality, emphasizing TFAP2C's role in regulating cell lineage commitment, hormone signaling, and cancer progression.
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