Thrombomodulin (THBD) Antibody
52€ (10 µg)
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Name
Thrombomodulin (THBD) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx014946
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against THBD protein. Immunogen region is C-terminal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Thrombomodulin (THBD) Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human THBD. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07204 |
| Alias | Fetomodulin, TM,THRM,AHUS6,BDCA3,CD141,BDCA-3,THPH12 |
| Background | Antibody anti-THBD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Thrombomodulin (THBD) is an endothelial cell membrane protein with critical anticoagulant properties. It serves as a cofactor in thrombin-mediated activation of protein C, which plays a significant role in regulating blood coagulation and maintaining vascular integrity. Beyond hemostasis, thrombomodulin is involved in numerous physiological functions, including inflammation control, cell proliferation, and protection against oxidative stress. Its expression is most prominent on endothelial cells lining the blood vessels but can also be found in other cell types, such as epithelial and some immune cells. Because of its crucial role in anticoagulation and endothelial function, thrombomodulin dysregulation is associated with various vascular, inflammatory, and coagulation disorders, as well as certain cancer types.
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