Thrombomodulin (THBD) Antibody
312€ (60 µl)
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935106861
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name
Thrombomodulin (THBD) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx003069
tested applications
WB, IHC, IF/ICC
Description
THBD Antibody is a Rabbit Polyclonal antibody against THBD. The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Thrombomodulin (THBD) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07204 |
| Gene ID | 7056 |
| NCBI Accession | NP_000352.1 |
| Alias | Fetomodulin, TM,THRM,AHUS6,BDCA3,CD141,BDCA-3,THPH12 |
| Background | Antibody anti-THBD |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Thrombomodulin (THBD) is an endothelial cell membrane protein with critical anticoagulant properties. It serves as a cofactor in thrombin-mediated activation of protein C, which plays a significant role in regulating blood coagulation and maintaining vascular integrity. Beyond hemostasis, thrombomodulin is involved in numerous physiological functions, including inflammation control, cell proliferation, and protection against oxidative stress. Its expression is most prominent on endothelial cells lining the blood vessels but can also be found in other cell types, such as epithelial and some immune cells. Because of its crucial role in anticoagulation and endothelial function, thrombomodulin dysregulation is associated with various vascular, inflammatory, and coagulation disorders, as well as certain cancer types.
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