Taste 2 Receptor Member 43 (TAS2R43) Antibody
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Description
Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May acts as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Taste 2 Receptor Member 43 (TAS2R43) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P59537 |
| Alias | TAS2R43,T2R52,taste receptor type 2 member 43 |
| Background | Antibody anti-TAS2R43 |
| Status | RUO |
Descripción
TAS2R43 is part of the bitter taste receptor family, specifically responsible for detecting bitter compounds. This receptor is expressed in taste cells on the tongue, where it responds to various bitter molecules. Upon binding with bitter ligands, TAS2R43 activates intracellular signaling pathways that lead to the perception of bitterness. This process is part of the body's protective mechanism, alerting the individual to potentially toxic or harmful substances commonly associated with bitter tastes. The sensitivity of TAS2R43 to specific bitter compounds can vary depending on genetic factors, contributing to individual differences in taste preferences. TAS2R43 is important for understanding how the body detects bitter substances, influencing dietary choices and food aversions. Studying this receptor may offer insights into food product design, particularly for reducing bitterness or understanding the genetic basis of food preferences.
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