Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
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Description
STIP1 mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Stress-Induced-Phosphoprotein 1 (STIP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P31948 |
| Alias | STAP1,BRDG1, STAP-1, signal transducing adaptor family member 1 |
| Background | Antibody anti-STAP1 |
| Status | RUO |
Descripción
STAP1 is an SH2 domain-containing adaptor protein that regulates cytokine receptor and tyrosine kinase signaling pathways. It interacts with proteins like c-Kit and Jak kinases to mediate downstream activation of signaling cascades such as MAPK, PI3K/Akt, and STAT pathways, influencing cellular proliferation, survival, and differentiation. STAP1 is expressed in hematopoietic and immune cells, where it modulates cytokine responses, immune cell activation, and differentiation. Dysregulation of STAP1 has been linked to immune dysfunction, leukemia, and certain inflammatory disorders due to its role in promoting cytokine-mediated signaling and hematopoietic regulation. Knockdown studies demonstrate impaired cytokine signaling, reduced proliferation, and abnormal immune responses, highlighting its role in fine-tuning signaling pathways during immune regulation and hematopoiesis.
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Mediates the association of the molecular chaperones HSC70 and HSP90(HSPCA and HSPCB).
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Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
STIP1 Antibody is a Rabbit Polyclonal antibody against STIP1. STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]). [supplied by OMIM, Jul 2009]
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