Stimulated By Retinoic Acid Gene 13 Protein Homolog (STRA13) Antibody

Este producto es parte de CENPX - Centromere protein X
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169€ (20 µg)

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935106861
info@markelab.com
name
Stimulated By Retinoic Acid Gene 13 Protein Homolog (STRA13) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx301294
tested applications
ELISA, IHC

Description

STRA13 Antibody is a Rabbit Polyclonal against STRA13.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Stimulated By Retinoic Acid Gene 13 Protein Homolog (STRA13)
Host
Rabbit
Reactivity
Human
Recommended Dilution
IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
A8MT69
Gene ID
201254
NCBI Accession
NP_001257935.1, NM_001271006.1
OMIM
615128
Alias
FAAP10,MHF2,STRA13,CENP-X,D9
Background
Antibody anti-CENPX
Status
RUO

Descripción

STRA13, also known as CENPX, is a member of the basic helix-loop-helix (bHLH) family of transcription factors. STRA13 is upregulated in response to retinoic acid, hypoxia, and other cellular stress signals, where it functions as a transcriptional repressor or activator depending on its interaction partners. It regulates processes such as cell cycle progression, apoptosis, immune responses, and metabolic pathways. STRA13 plays a crucial role in hypoxia-inducible factor (HIF)-mediated responses by suppressing cell proliferation and modulating oxygen-dependent pathways. It is highly expressed in immune cells, cancer tissues, and hypoxic environments, where it controls inflammatory cytokine production and enhances cellular survival under low oxygen. Dysregulation of STRA13 is associated with cancer progression, immune dysregulation, and metabolic disorders. Loss-of-function studies reveal defects in immune regulation, impaired response to hypoxia, and abnormal cell proliferation, emphasizing its role in stress adaptation, transcriptional regulation, and homeostasis maintenance.

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