Stimulated By Retinoic Acid Gene 13 Protein Homolog (STRA13) Antibody
312€ (60 µl)
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935106861
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name
Stimulated By Retinoic Acid Gene 13 Protein Homolog (STRA13) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx135836
tested applications
WB
Description
STRA13 Antibody is a Rabbit Polyclonal against STRA13.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Stimulated By Retinoic Acid Gene 13 Protein Homolog (STRA13) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A8MT69 |
| Gene ID | 201254 |
| NCBI Accession | NP_659435.2 |
| Alias | FAAP10,MHF2,STRA13,CENP-X,D9 |
| Background | Antibody anti-CENPX |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
STRA13, also known as CENPX, is a member of the basic helix-loop-helix (bHLH) family of transcription factors. STRA13 is upregulated in response to retinoic acid, hypoxia, and other cellular stress signals, where it functions as a transcriptional repressor or activator depending on its interaction partners. It regulates processes such as cell cycle progression, apoptosis, immune responses, and metabolic pathways. STRA13 plays a crucial role in hypoxia-inducible factor (HIF)-mediated responses by suppressing cell proliferation and modulating oxygen-dependent pathways. It is highly expressed in immune cells, cancer tissues, and hypoxic environments, where it controls inflammatory cytokine production and enhances cellular survival under low oxygen. Dysregulation of STRA13 is associated with cancer progression, immune dysregulation, and metabolic disorders. Loss-of-function studies reveal defects in immune regulation, impaired response to hypoxia, and abnormal cell proliferation, emphasizing its role in stress adaptation, transcriptional regulation, and homeostasis maintenance.
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