Signal Transducing Adaptor Family Member 1 Protein
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Description
STAP1 is a recombinant protein.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | STAP1 |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | Q9ULZ2 |
| Alias | STAP1,BRDG1, STAP-1, signal transducing adaptor family member 1 |
| Background | Protein STAP1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
STAP1 is an SH2 domain-containing adaptor protein that regulates cytokine receptor and tyrosine kinase signaling pathways. It interacts with proteins like c-Kit and Jak kinases to mediate downstream activation of signaling cascades such as MAPK, PI3K/Akt, and STAT pathways, influencing cellular proliferation, survival, and differentiation. STAP1 is expressed in hematopoietic and immune cells, where it modulates cytokine responses, immune cell activation, and differentiation. Dysregulation of STAP1 has been linked to immune dysfunction, leukemia, and certain inflammatory disorders due to its role in promoting cytokine-mediated signaling and hematopoietic regulation. Knockdown studies demonstrate impaired cytokine signaling, reduced proliferation, and abnormal immune responses, highlighting its role in fine-tuning signaling pathways during immune regulation and hematopoiesis.
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