SH2 Domain Containing 3C (SH2D3C) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
SH2 Domain Containing 3C (SH2D3C) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx237823
tested applications
ELISA, WB, IHC, IP
Description
SH2D3C Antibody is a Rabbit Polyclonal against SH2D3C.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 Domain Containing 3C (SH2D3C) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N5H7 |
| Gene ID | 10044 |
| OMIM | 604722 |
| Alias | SH2D3C, Sh2d3c, Chat, Nsp3, Shep1, PRO34088, SH2 domain containing 3C |
| Background | Antibody anti-SH2D3C |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
SH2D3C, also called NSP3, is an SH2 domain-containing adaptor protein that functions as a mediator of integrin and receptor tyrosine kinase signaling. It interacts with proteins like p130Cas and focal adhesion kinase (FAK) to regulate actin cytoskeleton reorganization, cell adhesion, and migration. SH2D3C is highly expressed in tissues with high cellular turnover and motility, including epithelial and immune tissues, where it participates in dynamic signaling processes essential for tissue remodeling and immune cell trafficking. It plays a critical role in linking extracellular cues to intracellular pathways, such as MAPK and PI3K/Akt, during processes like cell growth, differentiation, and survival. Dysregulation of SH2D3C has been associated with cancer, where it enhances cell motility and promotes metastasis by modulating focal adhesion turnover. Knockout models demonstrate impaired cellular adhesion, reduced migration, and altered signaling responses to growth factors, highlighting its role in coordinating cytoskeletal dynamics and signal transduction.
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