SH2 Domain Containing 3C (SH2D3C) Antibody

Background

SH2D3C, also called NSP3, is an SH2 domain-containing adaptor protein that functions as a mediator of integrin and receptor tyrosine kinase signaling. It interacts with proteins like p130Cas and focal adhesion kinase (FAK) to regulate actin cytoskeleton reorganization, cell adhesion, and migration. SH2D3C is highly expressed in tissues with high cellular turnover and motility, including epithelial and immune tissues, where it participates in dynamic signaling processes essential for tissue remodeling and immune cell trafficking. It plays a critical role in linking extracellular cues to intracellular pathways, such as MAPK and PI3K/Akt, during processes like cell growth, differentiation, and survival. Dysregulation of SH2D3C has been associated with cancer, where it enhances cell motility and promotes metastasis by modulating focal adhesion turnover. Knockout models demonstrate impaired cellular adhesion, reduced migration, and altered signaling responses to growth factors, highlighting its role in coordinating cytoskeletal dynamics and signal transduction.