SH2D3C antibody
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935106861
info@markelab.com
name
SH2D3C antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07823
tested applications
ELISA, WB, IHC, IP
Description
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 domain containing 3C (SH2D3C) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 77 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8N5H7 |
| Gene ID | 10044 |
| Alias | SH2D3C, Sh2d3c, Chat, Nsp3, Shep1, PRO34088, SH2 domain containing 3C |
| Background | Antibody anti-SH2D3C |
| Status | RUO |
| Note | Mol. Weight 77 kDa |
Descripción
SH2D3C, also called NSP3, is an SH2 domain-containing adaptor protein that functions as a mediator of integrin and receptor tyrosine kinase signaling. It interacts with proteins like p130Cas and focal adhesion kinase (FAK) to regulate actin cytoskeleton reorganization, cell adhesion, and migration. SH2D3C is highly expressed in tissues with high cellular turnover and motility, including epithelial and immune tissues, where it participates in dynamic signaling processes essential for tissue remodeling and immune cell trafficking. It plays a critical role in linking extracellular cues to intracellular pathways, such as MAPK and PI3K/Akt, during processes like cell growth, differentiation, and survival. Dysregulation of SH2D3C has been associated with cancer, where it enhances cell motility and promotes metastasis by modulating focal adhesion turnover. Knockout models demonstrate impaired cellular adhesion, reduced migration, and altered signaling responses to growth factors, highlighting its role in coordinating cytoskeletal dynamics and signal transduction.
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