Human SH2 Domain Containing 3C (SH2D3C) ELISA Kit

Name: Human SH2 Domain Containing 3C (SH2D3C) ELISA Kit
Brand: Abbexa
SKU: abx383170
Price: 715 EUR
Availability: OnlineOnly

Este producto es parte de SH2D - SH2 domain containing

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for SH2D3C

proveedor

Abbexa

reference

abx383170

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human SH2 Domain Containing 3C (SH2D3C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH2D3C concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

SH2D3C, also called NSP3, is an SH2 domain-containing adaptor protein that functions as a mediator of integrin and receptor tyrosine kinase signaling. It interacts with proteins like p130Cas and focal adhesion kinase (FAK) to regulate actin cytoskeleton reorganization, cell adhesion, and migration. SH2D3C is highly expressed in tissues with high cellular turnover and motility, including epithelial and immune tissues, where it participates in dynamic signaling processes essential for tissue remodeling and immune cell trafficking. It plays a critical role in linking extracellular cues to intracellular pathways, such as MAPK and PI3K/Akt, during processes like cell growth, differentiation, and survival. Dysregulation of SH2D3C has been associated with cancer, where it enhances cell motility and promotes metastasis by modulating focal adhesion turnover. Knockout models demonstrate impaired cellular adhesion, reduced migration, and altered signaling responses to growth factors, highlighting its role in coordinating cytoskeletal dynamics and signal transduction.

Características del producto

immunogen target

SH2 Domain Containing 3C (SH2D3C)

reactivity

Human

test range

0.313 ng/ml - 20 ng/ml

sensitivity

< 0.188 ng/ml

assay type

Sandwich

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

alias

SH2D3C, Sh2d3c, Chat, Nsp3, Shep1, PRO34088, SH2 domain containing 3C

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

SH2D3C

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q8N5H7

gene id

https://www.ncbi.nlm.nih.gov/gene/10044

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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reference

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Tested Applications

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reactivity

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status

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clonality

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SH2 Domain Containing 3C (SH2D3C) Antibody

proveedor

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reference

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Tested Applications

ELISA, WB, IHC, IP

reactivity

Human, Mouse, Rat

status

RUO

clonality

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