Human SH2 Domain Containing 3C (SH2D3C) ELISA Kit
715€ (96 tests)
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name
Human SH2 Domain Containing 3C (SH2D3C) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx383170
tested applications
ELISA
Description
Human SH2 Domain Containing 3C (SH2D3C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH2D3C concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH2 Domain Containing 3C (SH2D3C) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8N5H7 |
| Gene ID | 10044 |
| OMIM | 604722 |
| Alias | SH2D3C, Sh2d3c, Chat, Nsp3, Shep1, PRO34088, SH2 domain containing 3C |
| Background | Elisa kits for SH2D3C |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SH2D3C, also called NSP3, is an SH2 domain-containing adaptor protein that functions as a mediator of integrin and receptor tyrosine kinase signaling. It interacts with proteins like p130Cas and focal adhesion kinase (FAK) to regulate actin cytoskeleton reorganization, cell adhesion, and migration. SH2D3C is highly expressed in tissues with high cellular turnover and motility, including epithelial and immune tissues, where it participates in dynamic signaling processes essential for tissue remodeling and immune cell trafficking. It plays a critical role in linking extracellular cues to intracellular pathways, such as MAPK and PI3K/Akt, during processes like cell growth, differentiation, and survival. Dysregulation of SH2D3C has been associated with cancer, where it enhances cell motility and promotes metastasis by modulating focal adhesion turnover. Knockout models demonstrate impaired cellular adhesion, reduced migration, and altered signaling responses to growth factors, highlighting its role in coordinating cytoskeletal dynamics and signal transduction.
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