Name: Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
Brand: Abbexa
SKU: abx033693
Price: 281.25 EUR
Availability: OnlineOnly

Descripción

ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Background

ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

Serine/threonine-Protein Kinase Receptor R3 (ACVRL1)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC, FCM

purification

Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

ACVRL1

dry ice

availability

Shipped within 5-10 working days.

alias

Activin receptor-like kinase 1,ALK-1,SKR3

uniprot id

https://www.uniprot.org/uniprotkb/P37023

NCBI accession

NP_000011.2, NP_001070869.1

note

This product is for research use only.

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anti- ACVRL1 antibody

proveedor

FineTest

reference

FNab00131

Tested Applications

ELISA, WB, IHC, FC, IP

reactivity

human

status

RUO

clonality

polyclonal

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel developme...

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