Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
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935106861
info@markelab.com
Precio
281.25€ (80 µl)
Antibody anti-ACVRL1
proveedor
Abbexareference
abx033694Tested Applications
ELISA, WB, IHC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Background
ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Serine/threonine-Protein Kinase Receptor R3 (ACVRL1)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, FCM
purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ACVRL1
dry ice
No
availability
Shipped within 5-10 working days.
alias
Activin receptor-like kinase 1,ALK-1,SKR3
uniprot id
note
This product is for research use only.
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proveedor
Abbexareference
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ELISA, WB, IHC, FCMreactivity
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RUOclonality
PolyclonalACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors ...
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Ver másSerine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
proveedor
Abbexareference
abx033694Tested Applications
ELISA, WB, IHC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors ...
281.25€ (80 µl)
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