Secretin Receptor (SCTR) Antibody (HRP)
169€ (20 µg)
169€ (20 µg)
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935106861
info@markelab.com
name
Secretin Receptor (SCTR) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx317186
tested applications
ELISA
Descripción del producto
SCTR Antibody (HRP) is a Rabbit Polyclonal against SCTR conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| OMIM | 182098 |
| Alias | SCTR,SCT-R,SR |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-SCTR |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 6344 |
| Host | Rabbit |
| Immunogen Target | Secretin Receptor (SCTR) |
| Isotype | IgG |
| Name | Secretin Receptor (SCTR) Antibody (HRP) |
| Price | 169 |
| Provider | Abbexa |
| Purification | Purified by Protein G. |
| Purity | > 95% |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx317186 |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA |
| UniProt ID | P47872 |
Descripcion del producto en español
Background en español
Secretin receptor (SCTR) is a G protein-coupled receptor (GPCR) activated by secretin, a peptide hormone that regulates water and bicarbonate secretion in the pancreas and gastrointestinal tract. SCTR is expressed primarily in the pancreas, small intestine, liver, and central nervous system. Upon activation, SCTR stimulates adenylyl cyclase, increasing cyclic AMP (cAMP) and activating protein kinase A (PKA), which drives bicarbonate secretion from pancreatic ductal cells, aiding in neutralizing gastric acid. SCTR also regulates gastric motility, bile secretion, and insulin release under certain metabolic states. Dysregulation of SCTR signaling has been implicated in pancreatic diseases, including chronic pancreatitis and pancreatic cancer, where altered secretin responses disrupt homeostasis. In the brain, SCTR plays a role in neuroprotection, learning, and mood regulation, with potential relevance to cognitive and emotional disorders. Targeting SCTR signaling is being explored for therapeutic applications in pancreatic diseases, gastrointestinal disorders, and metabolic regulation.
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