Satb Homeobox 1 (SATB1) Antibody
637€ (100 µl)
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Name
Satb Homeobox 1 (SATB1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx115383
Tested Applications
ELISA, WB
Description
Satb Homeobox 1 Antibody is a Rabbit Polyclonal antibody against Satb Homeobox 1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Satb Homeobox 1 (SATB1) Immunogen: Human SATB1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01826 |
| Gene ID | 6304 |
| NCBI Accession | NP_001124482.1, NM_001131010.3 |
| OMIM | 602075 |
| Alias | DEFDA,DHDBV,KTZSL,Special AT-Rich Sequence-Binding Protein 1,DNA-binding protein SATB1 |
| Background | Antibody anti-SATB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SATB homeobox 1 (SATB1) is a global chromatin organizer and transcription factor that regulates gene expression by binding to specialized DNA sequences and anchoring chromatin loops to the nuclear matrix SATB1 plays a critical role in cellular differentiation, development, and lineage commitment, particularly in the immune system and during T-cell development It modulates chromatin accessibility and acts as a scaffold to recruit chromatin-modifying enzymes, thereby influencing gene activation and repression SATB1 is highly expressed in tissues undergoing rapid cellular growth and differentiation Dysregulation of SATB1 has been linked to cancer progression and metastasis, particularly in breast cancer, where it promotes oncogenic gene expression and cell invasion SATB1 also contributes to immune regulation, influencing T-cell function and immune responses Studies highlight its role in neurodevelopment and stem cell maintenance, where it regulates the expression of lineage-specific genes Its ability to coordinate large-scale chromatin remodeling makes SATB1 a critical regulator of gene expression, cellular identity, and disease pathogenesis across various biological contexts
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