SATB Homeobox 1 (SATB1) Antibody
195€ (20 µl)
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Name
SATB Homeobox 1 (SATB1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx004443
Tested Applications
ELISA, WB, IHC, IF/ICC, IP
Description
SATB1 Antibody is a Rabbit Polyclonal antibody against SATB1. This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: SATB Homeobox 1 (SATB1) Immunogen: Recombinant protein corresponding to SATB1. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 86 kDa Observed MW: 100 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01826 |
| Gene ID | 6304 |
| NCBI Accession | NP_002962.1 |
| Alias | DEFDA,DHDBV,KTZSL,Special AT-Rich Sequence-Binding Protein 1,DNA-binding protein SATB1 |
| Background | Antibody anti-SATB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SATB homeobox 1 (SATB1) is a global chromatin organizer and transcription factor that regulates gene expression by binding to specialized DNA sequences and anchoring chromatin loops to the nuclear matrix SATB1 plays a critical role in cellular differentiation, development, and lineage commitment, particularly in the immune system and during T-cell development It modulates chromatin accessibility and acts as a scaffold to recruit chromatin-modifying enzymes, thereby influencing gene activation and repression SATB1 is highly expressed in tissues undergoing rapid cellular growth and differentiation Dysregulation of SATB1 has been linked to cancer progression and metastasis, particularly in breast cancer, where it promotes oncogenic gene expression and cell invasion SATB1 also contributes to immune regulation, influencing T-cell function and immune responses Studies highlight its role in neurodevelopment and stem cell maintenance, where it regulates the expression of lineage-specific genes Its ability to coordinate large-scale chromatin remodeling makes SATB1 a critical regulator of gene expression, cellular identity, and disease pathogenesis across various biological contexts
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