Retinoic Acid Receptor RXR-Beta (RXRB) Antibody
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Description
RXRB Antibody is a Rabbit Polyclonal against RXRB.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Retinoic Acid Receptor RXR-Beta (RXRB) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28702 |
| Gene ID | 6257 |
| NCBI Accession | NP_001257330.1, NM_001270401.1, NP_068811.1, NM_021976.4 |
| OMIM | 180246 |
| Alias | NR2B2,DAUDI6,RCoR-1,RXRbeta,H-2RIIBP,RXR-beta,Retinoic acid receptor RXR-beta,Retinoid X receptor beta,Nuclear receptor subfamily 2 group B member 2 |
| Background | Antibody anti-RXRB |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Retinoid X receptor beta (RXRB) is another member of the RXR family, with a role in mediating the effects of retinoids and regulating gene expression RXRB forms heterodimers with RXRA and other nuclear receptors, influencing various physiological processes including lipid metabolism, cellular differentiation, and inflammation It is widely expressed in tissues such as the liver, brain, and heart, where it regulates the expression of genes involved in fat metabolism, cholesterol homeostasis, and glucose metabolism RXRB also plays an important role in the immune system, where it helps modulate the activity of immune cells and inflammatory responses Dysregulation of RXRB has been implicated in metabolic diseases, such as obesity and type 2 diabetes, as well as cardiovascular diseases where altered lipid metabolism and inflammation contribute to disease progression RXRB represents a potential therapeutic target for the treatment of metabolic disorders, inflammatory diseases, and cancer
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