Retinoic Acid Receptor RXR-Beta (RXRB) Antibody
292.5€ (80 µl)
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Name
Retinoic Acid Receptor RXR-Beta (RXRB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx034505
Tested Applications
ELISA, WB
Description
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Retinoic Acid Receptor RXR-Beta (RXRB) Immunogen: KLH-conjugated synthetic peptide between 256-284 amino acids from the Central region of human RXRB. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 56.9 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28702 |
| Alias | NR2B2,DAUDI6,RCoR-1,RXRbeta,H-2RIIBP,RXR-beta,Retinoic acid receptor RXR-beta,Retinoid X receptor beta,Nuclear receptor subfamily 2 group B member 2 |
| Background | Antibody anti-RXRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Retinoid X receptor beta (RXRB) is another member of the RXR family, with a role in mediating the effects of retinoids and regulating gene expression RXRB forms heterodimers with RXRA and other nuclear receptors, influencing various physiological processes including lipid metabolism, cellular differentiation, and inflammation It is widely expressed in tissues such as the liver, brain, and heart, where it regulates the expression of genes involved in fat metabolism, cholesterol homeostasis, and glucose metabolism RXRB also plays an important role in the immune system, where it helps modulate the activity of immune cells and inflammatory responses Dysregulation of RXRB has been implicated in metabolic diseases, such as obesity and type 2 diabetes, as well as cardiovascular diseases where altered lipid metabolism and inflammation contribute to disease progression RXRB represents a potential therapeutic target for the treatment of metabolic disorders, inflammatory diseases, and cancer
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