Receptor-type tyrosine-protein phosphatase T (PTPRT) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Receptor-type tyrosine-protein phosphatase T (PTPRT) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212202
tested applications
ELISA, IHC
Description
PTPRT Antibody is a Rabbit Polyclonal against PTPRT.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor-type tyrosine-protein phosphatase T (PTPRT) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14522 |
| Gene ID | 11122 |
| Alias | R-PTP-T,RPTPrho,RPTP-rho,Receptor-type tyrosine-protein phosphatase rho,R-PTP-T,Receptor-type tyrosine-protein phosphatase T |
| Background | Antibody anti-PTPRT |
| Status | RUO |
Descripción
PTPRT is a receptor-type protein tyrosine phosphatase critical for cell adhesion, neuronal development, and tumor suppression. Structurally, PTPRT features extracellular immunoglobulin (Ig)-like and fibronectin type III domains, a transmembrane domain, and two intracellular phosphatase domains, one of which is catalytically active. PTPRT is predominantly expressed in the central nervous system, particularly in neurons, where it regulates synaptic formation and maintenance. It interacts with cadherins and β-catenin to control cell-cell adhesion and neuronal connectivity. PTPRT acts as a tumor suppressor by dephosphorylating STAT3, a transcription factor involved in promoting cell survival and proliferation. Mutations or inactivation of PTPRT have been identified in colorectal, lung, and gastric cancers, linking its dysregulation to tumorigenesis. PTPRT’s role in synaptic plasticity and cancer highlights its dual significance in neurological and oncogenic processes, making it a target for therapeutic intervention.
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