Human Receptor-type tyrosine-protein phosphatase T (PTPRT) ELISA Kit
715€ (96 tests)
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name
Human Receptor-type tyrosine-protein phosphatase T (PTPRT) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385358
tested applications
ELISA
Description
Human Receptor-type tyrosine-protein phosphatase T (PTPRT) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PTPRT concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Receptor-type tyrosine-protein phosphatase T (PTPRT) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O14522 |
| Gene ID | 11122 |
| OMIM | 608712 |
| Alias | R-PTP-T,RPTPrho,RPTP-rho,Receptor-type tyrosine-protein phosphatase rho,R-PTP-T,Receptor-type tyrosine-protein phosphatase T |
| Background | Elisa kits for PTPRT |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PTPRT is a receptor-type protein tyrosine phosphatase critical for cell adhesion, neuronal development, and tumor suppression. Structurally, PTPRT features extracellular immunoglobulin (Ig)-like and fibronectin type III domains, a transmembrane domain, and two intracellular phosphatase domains, one of which is catalytically active. PTPRT is predominantly expressed in the central nervous system, particularly in neurons, where it regulates synaptic formation and maintenance. It interacts with cadherins and β-catenin to control cell-cell adhesion and neuronal connectivity. PTPRT acts as a tumor suppressor by dephosphorylating STAT3, a transcription factor involved in promoting cell survival and proliferation. Mutations or inactivation of PTPRT have been identified in colorectal, lung, and gastric cancers, linking its dysregulation to tumorigenesis. PTPRT’s role in synaptic plasticity and cancer highlights its dual significance in neurological and oncogenic processes, making it a target for therapeutic intervention.
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