Rat Signal Transducing Adaptor Protein 1 (STAP1) Protein

Este producto es parte de STAP - Signal-transducing adaptor protein
Rat Signal Transducing Adaptor Protein 1 (STAP1) Protein
247€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Rat Signal Transducing Adaptor Protein 1 (STAP1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx166139
Tested Applications
WB, SDS-PAGE

Description

Rat Signal Transducing Adaptor Protein 1 is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Signal Transducing Adaptor Protein 1 (STAP1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Met1-Ala297
Tag: N-terminal His tag
Origin
Rat
Conjugation
Unconjugated
Observed MW
Calculated MW: 38.2 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
STAP1,BRDG1, STAP-1, signal transducing adaptor family member 1
Background
Protein STAP1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

STAP1 is an SH2 domain-containing adaptor protein that regulates cytokine receptor and tyrosine kinase signaling pathways. It interacts with proteins like c-Kit and Jak kinases to mediate downstream activation of signaling cascades such as MAPK, PI3K/Akt, and STAT pathways, influencing cellular proliferation, survival, and differentiation. STAP1 is expressed in hematopoietic and immune cells, where it modulates cytokine responses, immune cell activation, and differentiation. Dysregulation of STAP1 has been linked to immune dysfunction, leukemia, and certain inflammatory disorders due to its role in promoting cytokine-mediated signaling and hematopoietic regulation. Knockdown studies demonstrate impaired cytokine signaling, reduced proliferation, and abnormal immune responses, highlighting its role in fine-tuning signaling pathways during immune regulation and hematopoiesis.

Productos relacionados

abx001131

Stress-Induced-Phosphoprotein 1 (STIP1) Antibody

STIP1 Antibody is a Rabbit Polyclonal antibody against STIP1. STIP1 is an adaptor protein that coordinates the functions…

Ver producto
abx031725

Stress-Induced-Phosphoprotein 1 (STIP1) Antibody

STIP1 mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).…

Ver producto
abx031726

Stress-Induced-Phosphoprotein 1 (STIP1) Antibody

STIP1 mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).…

Ver producto