Rat Signal Transducing Adaptor Protein 1 (STAP1) Protein
247€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Rat Signal Transducing Adaptor Protein 1 (STAP1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx166139
Tested Applications
WB, SDS-PAGE
Description
Rat Signal Transducing Adaptor Protein 1 is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Signal Transducing Adaptor Protein 1 (STAP1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Ala297 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 38.2 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | STAP1,BRDG1, STAP-1, signal transducing adaptor family member 1 |
| Background | Protein STAP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
STAP1 is an SH2 domain-containing adaptor protein that regulates cytokine receptor and tyrosine kinase signaling pathways. It interacts with proteins like c-Kit and Jak kinases to mediate downstream activation of signaling cascades such as MAPK, PI3K/Akt, and STAT pathways, influencing cellular proliferation, survival, and differentiation. STAP1 is expressed in hematopoietic and immune cells, where it modulates cytokine responses, immune cell activation, and differentiation. Dysregulation of STAP1 has been linked to immune dysfunction, leukemia, and certain inflammatory disorders due to its role in promoting cytokine-mediated signaling and hematopoietic regulation. Knockdown studies demonstrate impaired cytokine signaling, reduced proliferation, and abnormal immune responses, highlighting its role in fine-tuning signaling pathways during immune regulation and hematopoiesis.
Productos relacionados
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
STIP1 Antibody is a Rabbit Polyclonal antibody against STIP1. STIP1 is an adaptor protein that coordinates the functions…
Ver producto
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
STIP1 mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).…
Ver producto
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
STIP1 mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).…
Ver producto